Sophia Ogechi Ekeuku1,
Kok-Yong Chin1,2,
Nur Zuliani Ramli3,4,
Khairul Anwar Zarkasi4,5,
Fairus Ahmad3 
For correspondence:- Fairus Ahmad Email: fairusahmad@ukm.edu.my Tel:+60391458632
Accepted: 25 May 2021 Published: 30 June 2021
Citation: Ekeuku SO, Chin K, Ramli NZ, Zarkasi KA, Ahmad F. Effect of Kelulut honey supplementation on bone health in male rats on high-carbohydrate high-fat diet. Trop J Pharm Res 2021; 20(6):1185-1192 doi: 10.4314/tjpr.v20i6.13
© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To determine the effects of Kelulut honey (KH) on the bone health of rats with metabolic syndrome.
Methods: Male Wistar rats were randomised into normal control and metabolic syndrome s fed with a diet enriched with carbohydrate and fat. The rats in the metabolic syndrome arm were further assigned into the negative control group and honey group supplemented orally with Kelulut honey (1g/kg) daily for eight weeks. After the rats were sacrificed, the trabecular and cortical micro-architecture of the harvested femur was analysed using X-ray micro-computed tomography, while histomorphometric method was used to determine bone cell indices. Femoral biomechanical properties were analysed using a universal mechanical tester.
Results: Total cross-sectional area, osteoid surface and volume, displacement and strain reduced significantly, while eroded surface increased significantly in the rats with metabolic syndrome than the normal rats (p < 0.05). The honey group showed a significant reduction in osteoclast surface than the normal healthy control (p < 0.05). Other skeletal parameters did not show a significant intergroup difference.
Conclusion: Metabolic syndrome is harmful to bone health and honey has limited effects in reversing these negative effects.
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