Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Sensitive and rapid spectrophotometric methods for sertraline monitoring in pharmaceutical formulations

Ali Sayqal¹, Amr Lotfy Saber^1,2

¹Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia; ²Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt.

For correspondence:- Amr Saber Email: alshefny@yahoo.com

Accepted: 17 May 2021 Published: 30 June 2021

Citation: Sayqal A, Saber AL. Sensitive and rapid spectrophotometric methods for sertraline monitoring in pharmaceutical formulations. Trop J Pharm Res 2021; 20(6):1233-1239 doi: 10.4314/tjpr.v20i6.20

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To develop simple, rapid, and selective spectrophotometric methods for the assay of sertraline in a pharmaceutical formulation.

Method: These methods depend on the formation of colored ion-pair complexes between the drug and five different reagents; methyl blue (MB), bromophenol red (BPR), methyl green (MG), phenol red (PR), and methyl orange (MO) in B-R buffer solutions of pH ranging from 2.0 – 8.0. The colored products were measured at 668, 747, 647, 717, and 553 nm, respectively.

Results: The calibration graphs were linear over the concentration range of 2 – 18 µg/mL for MB and BPR, and 2 – 16 µg/mL for MG, PR, and MO. In all cases, the reaction stoichiometry was 1:1. The proposed methods were successfully applied to solid-dose pharmaceutical preparations (tablets). Excipients in the commercial formulation did not interfere with the analysis.

Conclusion: The investigated methods can be recommended for routine analysis and quality control where cost-effectiveness, high specificity of the analytical technique, and time are of great importance.

Keywords: Sertraline, Ion pair complex, Spectrophotometry, Pharmaceutical