Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of a combination of low-dose aminophylline and budesonide on lung function, serum inflammatory factors and quality of life of patients with chronic obstructive pulmonary disease

Shuli Zhang¹, Qingfeng Liu², Zhaojun Chu³, Lili Wang⁴, Fangchao Jiang⁵

¹Department of Pharmacy, Jiaozhou Central Hospital of Qingdao; ²Department of Internal Medicine, Shandong Qingdao Integrated Traditional Chinese and Western Medicine Hospital, Shandong Province; ³Department of Respiratory and Critical Care Medicine, Zaozhuang Hospital, Zaozhuang Mining Group; ⁴Department of Respiratory Medicine, Shandong Qingdao Integrated Traditional Chinese and Western Medicine Hospital; ⁵Department of General Practice, Qingdao Hospital of Traditional Chinese Medicine, Qingdao Hiser Hospital, Shandong Province, China.

For correspondence:- Fangchao Jiang Email: gansichiaomhz@163.com Tel:+8618560609616

Accepted: 26 May 2021 Published: 30 June 2021

Citation: Zhang S, Liu Q, Chu Z, Wang L, Jiang F. Effect of a combination of low-dose aminophylline and budesonide on lung function, serum inflammatory factors and quality of life of patients with chronic obstructive pulmonary disease. Trop J Pharm Res 2021; 20(6):1273-1278 doi: 10.4314/tjpr.v20i6.25

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effect of a combination of low-dose aminophylline and budesonide on lung function, serum inflammatory factors and quality of life of patients with chronic obstructive pulmonary disease (COPD).

Methods: A total of 120 COPD patients admitted to Jiaozhou Central Hospital of Qingdao from January 2018 to January 2019 were the subjects for this study. They were divided into two groups based on the order of admission, with 60 patients in each group. The two groups of patients were treated with conventional COPD therapy. In addition, patients in group B were treated with budesonide, while those in group A were treated with a combination of low-dose aminophylline and budesonide. Lung function indices, serum levels of inflammatory factors, quality of life (QOL), 6-min walking distance (6MWD), and overall treatment effectiveness in the two groups were compared.

Results: Lung function indices were significantly higher in group A than in group B, while patients in group A had significantly lower serum levels of inflammatory factors than patients in group B (p < 0.001). There was markedly higher QOL in group A patients than in patients of group B, but patients in group A achieved longer 6MWD than group B patients (p < 0.001). More patients showed treatment effectiveness in group A than in group B (p < 0.05).

Conclusion: Treatment with a combination of low-dose aminophylline and budesonide effectively improves lung function indices in COPD patients, reduces serum levels of inflammatory factors, but enhances their QOL. Thus, the combination treatment may be clinically beneficial to COPD patients.

Keywords: Aminophylline, Budesonide, Chronic obstructive pulmonary disease (COPD), Lung function