Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effects of a combination of moxapride and fluoxetine on gastrointestinal function in patients with functional dyspepsia-associated anxiety

Yan Wang , Mengchun Wang, Yan Li

Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning, China;

For correspondence:- Yan Wang Email: jiaoleweicuzw@163.com Tel:+8618940259626

Accepted: 29 May 2021 Published: 30 June 2021

Citation: Wang Y, Wang M, Li Y. Effects of a combination of moxapride and fluoxetine on gastrointestinal function in patients with functional dyspepsia-associated anxiety. Trop J Pharm Res 2021; 20(6):1293-1298 doi: 10.4314/tjpr.v20i6.28

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To study the effects of a combination of mosapride and fluoxetine in patients with functional dyspepsia-associated anxiety, and its impact on gastrointestinal function.

Methods: One hundred (100) cases of patients with anxiety linked to functional dyspepsia, who were admitted to the Department of Gastroenterology of Shengjing Hospital, China Medical University from January 2019 to May 2020, were retrospectively selected and randomly divided into control and study groups (n = 50). The control group patients received moxapride monotherapy, while those in the study group were given moxapride in combination with fluoxetine. The two groups of patients were compared daily for 4 days with respect to treatment effectiveness, Mental Status Scale in Non-psychiatric Settings (MSSNS), Barthel Index (BI), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), time intervals for flatulence and defecation, as well as bowel sounds, and levels of gastric juice and cholecystokinin.

Results: Treatment effectiveness, BI index, number of intestinal rumblings, and level of gastrin in the study group were significantly higher than those in control group after 1, 2, 3 and 4 days of treatment (p < 0.05). Moreover, scores for SAS, SDS and MSSNS, as well as time intervals for flatulence and defecation, and level cholecystokinin in the study group were significantly lower than those in control group (p < 0.05).

Conclusion: The combination of mosapride and fluoxetine has high application benefit for patients with anxiety associated with functional dyspepsia when compared with the control.

Keywords: Mosapride, Fluoxetine, Functional dyspepsia, Anxiety; Gastrointestinal function, Gastrin, Cholecystokinin