Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Factors that influence deep vein thrombosis of lower limbs in stroke patients, and the effect of anticoagulant intervention

Guang Zhou¹, Zheng Li², Lei Sun³, Hongjuan Wang⁴, Qinghua Li¹

¹Department of Rehabilitation Medicine, Jiaozhou Central Hospital of Qingdao, Jiaozhou, Qingdao; ²Emergency Department, Shandong Qingdao Integrated Traditional Chinese and Western Medicine Hospital; ³International Clinic, Qingdao Central Hospital Group, Qingdao; ⁴Department of Encephalopathy, Shandong Qingdao Integrated Traditional Chinese and Western Medicine Hospital; ⁵Department of Neurosurgery, AnQiu People's Hospital, Anqiu, China.

For correspondence:- Qinghua Li Email: doubeiyuecuoozmvnu@163.com

Accepted: 25 May 2021 Published: 30 June 2021

Citation: Zhou G, Li Z, Sun L, Wang H, Li Q. Factors that influence deep vein thrombosis of lower limbs in stroke patients, and the effect of anticoagulant intervention. Trop J Pharm Res 2021; 20(6):1299-1305 doi: 10.4314/tjpr.v20i6.29

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the factors influencing deep vein thrombosis (DVT) in stroke patients, and the effect of anticoagulant intervention.

Methods: A total of 208 stroke patients in Jiaozhou Central Hospital of Qingdao from March 2018 to March 2020 were assigned to DVT group (n = 84) and non-DVT group (n = 124). Their clinical data were analyzed to identify risk factors. Thereafter, the DVT group were randomized to control group and study group (n = 42 each). Conventional treatment and low molecular heparin plus treatment were given to the groups, respectively. Activities of daily living (ADL) and treatment outcomes were compared.

Results: Univariate analysis showed that age, smoking history, Wells score, duration of bed rest, limb immobilization time after interventional therapy, D-dimer and TGs differed between the two groups (p < 0.05). Multivariate logistic regression analysis revealed that age ≥ 60 years old, smoking history, Wells score ≥ 2 points, duration of bed-rest ≥ 7 days, limb immobilization time ≥ 1 day after intervention, D-dimer < 0.95 mg/L and TG < 1.84 mmol/L were risk factors for DVT. After treatment, ADL and total treatment effectiveness in the study group were higher than in the control group (p < 0.05).

Conclusion: Age ≥ 60 years, smoking history, Wells score ≥ 2 points, duration of bedrest ≥ 7 days, limb immobilization time ≥ 1 day after intervention, D-dimer < 0.95 mg/L and TG < 1.84 mmol/L are risk factors for DVT. The anticoagulant used (rivaroxaban) seems to improve daily living and reduce clinical symptoms.

Keywords: Stroke, Deep vein thrombosis, Anticoagulants, Intervention effect