Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Genetic polymorphisms of osteopontin in association with ankylosing spondylitis in a chinese population

Xiu-fang Wang, Yi Cai

Department of Pain, The Central Hospital of Wuhan, Wuhan, Hubei Province, 430021, China;

For correspondence:- Yi Cai Email: 187076605@qq.com

Received: 7 August 2015 Accepted: 5 November 2015 Published: 27 December 2015

Citation: Wang X, Cai Y. Genetic polymorphisms of osteopontin in association with ankylosing spondylitis in a chinese population. Trop J Pharm Res 2015; 14(12):2319-2323 doi: 10.4314/tjpr.v14i12.24

© 2015 The authors.
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Abstract

Purpose: To determine the association of osteopontin (OPN) polymorphisms with ankylosing spondylitis (AS).

Methods: A total of 120 cases diagnosed with AS and 106 age- and sex-matched healthy controls were recruited. All the patients were human leukocyte antigen (HLA)-B27 positive. Three single nucleotide polymorphisms were genotyped using direct sequencing

Results: The T allele at -443 SNP had significantly higher frequency in AS patients (0.1875) than the controls (0.1085, p < 0.01). The rate of CT+TT genotype in AS patients was significantly higher than those with CC genotype compared with the control (p < 0.01).

Conclusion: SNP at -443 of OPN gene can serve as a candidate genetic marker to evaluate the risk of AS, thus indicating that subjects who carry T allele have a significantly higher risk of developing AS.

Keywords: Genetic polymorphism, Ankylosing spondylitis, Osteopontin, Sequencing