Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Treatment of vulval condyloma with a combination of paiteling and cryotherapy, and its effect on late recurrence

Lijun Wang¹, Hongshuai Tian², Guiqing Liu³, Yan Yu³, Haili Li⁴, Leilei Chen³, Hongwei Xiong⁵

¹Department of Dermatology & Sexually Transmitted Diseases (STD); ²Department of Reproductive Health; ³Department of Obstetrics and Gynecology, The Second Children & Women's Health Care of Jinan City; ⁴Department of Obstetrics and Gynecology, Laiwu People's Hospital, Jinan 271100, Shandong; ⁵Department of Obstetrics and Gynecology, The Second People's Hospital of Huludao, Huludao 125000, Liaoning Province, China.

For correspondence:- Hongwei Xiong Email: hlderxhw@163.com

Accepted: hlderxhw@163.com Published: 31 August 2021

Citation: Wang L, Tian H, Liu G, Yu Y, Li H, Chen L, et al. Treatment of vulval condyloma with a combination of paiteling and cryotherapy, and its effect on late recurrence. Trop J Pharm Res 2021; 20(8):1749-1755 doi: 10.4314/tjpr.v20i8.28

© 2021 The authors.
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Abstract

Purpose: To study the clinical effectiveness of a combination of Paiteling and cryotherapy in the treatment of vulval condyloma acuminatum (VCA), and its effect on late recurrence.

Methods: Eighty-six VCA patients were chosen as research subjects, and were randomized into group A and group B. Group A patients were treated with combination of Paiteling and cryotherapy, while group B patients received cryotherapy only. The clinical effects of the two treatment methods on VCA were evaluated by measuring area of damaged skin, levels of interleukin-6 (IL-6) and C-reactive protein (CRP), as well as degree of recurrence of VCA in the two groups, before and after treatment.

Results: Total clinical treatment effectiveness in group A was significantly higher compared with group B (p < 0.05). After treatment, the area of damaged skin, and levels of IL-6 and CRP were markedly lower in group A than in group B (p < 0.001). After 6 months of treatment, disease control was higher in group A than in group B (p < 0.05). There was also a lower incidence of adverse reactions in group A than in group B (p < 0.05).

Conclusion: These results indicate that the combination of Paiteling and cryotherapy is more effective than cryotherapy alone in improving treatment effectiveness and reducing late recurrence of VCA. Therefore, the combined treatment has potentials clinical application in the management of VCA.

Keywords: Paiteling, Cryotherapy, Vulval condyloma acuminatum (VCA), Clinical efficacy, Late recurrence