Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

A study of the effect of combination of acupuncture and Chinese medicine (Ban Xia Xie Xin Decoction) on patients with sepsis-induced gastrointestinal dysfunction

Yanfei Lv^1,2, Feng Dong³, Hao Hao³, Li Kong³

¹Postdoctoral Mobile Station of Shandong University of Traditional Chinese Medicine; ²Department of Rehabilitation Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University; ³Department of Emergency and Critical Care Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong, China.

For correspondence:- Li Kong Email: shangfuna1037@163.com

Accepted: 19 August 2021 Published: 30 September 2021

Citation: Lv Y, Dong F, Hao H, Kong L. A study of the effect of combination of acupuncture and Chinese medicine (Ban Xia Xie Xin Decoction) on patients with sepsis-induced gastrointestinal dysfunction. Trop J Pharm Res 2021; 20(9):1983-1989 doi: 10.4314/tjpr.v20i9.27

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the therapeutic effect of combination of acupuncture and Ban Xia Xie Xin Decoction (BXXXD) in patients with sepsis-induced gastrointestinal dysfunction.

Methods: A total of 100 patients with sepsis and gastrointestinal dysfunction admitted to our hospital from June 2019 to December 2020 were randomly assigned to a control group and a study group for a retrospective analysis. Both groups received acupuncture treatment, while BXXXD was given to the study group, in addition to acupuncture. Treatment effectiveness, incidence of adverse reactions, degree of recurrence at 1, 2 and 3 months after treatment, gastrointestinal dysfunction scores after 1 week of treatment, quality of life index (QLI) scores, frequencies of flatulence and defecation within 48 h, number of bowel rumblings, as well as levels of gastrin and cholecystokinin (CCK), were determined and compared between the two groups.

Results: The group with BXXXD intervention demonstrated superior treatment effectiveness, QLI scores, frequencies of flatulence and defecation within 48 h, number of bowel rumblings, and level of gastrin than those who received only acupuncture treatment (p < 0.05). There was strong evidence of lower incidence of adverse reactions, recurrence at 1, 2, and 3 months after treatment; gastrointestinal dysfunction scores and CCK levels after 1 week of treatment was higher in the study group than in the control group (p < 0.05).

Conclusion: The combination of acupuncture and BXXXD is superior to acupuncture alone in sepsis patients with gastrointestinal dysfunction. The combination therapy produces its effect by decreasing clinical symptoms, promoting recovery of the patients, and elevating their quality of life.

Keywords: Acupuncture, Ban Xia Xie Xin Decoction, Sepsis, Gastrointestinal dysfunction, Quality of life