Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Efficacy and prognosis following combined cinepazaide maleate/nimodipine therapy in cerebral vasospasm patients after hemorrhage

Tao Wu¹, Fangshu Chen², Hanyan Xiao³, Tianying Xu³ ,

¹Department of Neurosurgery, Linyi Central Hospital, Linyi 276400, Shandong Province; ²Department of Neuro Intervention, Zhangqiu District People's Hospital, Jinan 250200, Shandong Province; ³Department of Neurology, The Second Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157010, Heilongjiang Province, China.

For correspondence:- Tianying Xu Email: tx3m2c@163.com Tel:+925190643223

Accepted: 22 August 2021 Published: 30 September 2021

Citation: Wu T, Chen F, Xiao H, Xu T, Efficacy and prognosis following combined cinepazaide maleate/nimodipine therapy in cerebral vasospasm patients after hemorrhage. Trop J Pharm Res 2021; 20(9):1999-2004 doi: 10.4314/tjpr.v20i9.29

© 2021 The authors.
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Abstract

Purpose: To investigate the efficacy and prognosis following treatment of cerebral vasospasm (CVS) patients with a combination of cinnarizide maleate and nimodipine after subarachnoid hemorrhage (SAH).

Methods: Eighty-eight patients with CVS after SAH were selected and divided into control group (CG) and study group (EG), each with 44 patients (n = 44). Patients in CG were treated with intravenous infusion of cinnarizide maleate, while those in EG received intravenous infusion of cinnarizide maleate together, and their clinical efficacy and prognosis were compared.

Results: Compared with CG, total treatment effectiveness (response) in EG was significantly higher, while levels of inflammatory factors were lower (p < 0.05). Serum protein levels of S100 β and ET-1, and MCA blood flow velocity in EG were notably lower (p < 0.05), but GCS scores were higher compared with CG (p < 0.05). The NIHSS scores were lower and BI indices were higher in EG than in CG (p < 0.05).

Conclusion: Treatment of CVS patients after SAH using a combination of cinnarizide maleate and nimodipine effectively reduces the levels of inflammatory factors, improves quality of prognosis, and relieves symptoms of CVS, when compared with administration of cinnarizide maleate only. Therefore, the combination treatment is recommended for the management of CVS after SAH.

Keywords: Cinnarizide maleate, Nimodipine, Cerebral vasospasm (CVS), Subarachnoid hemorrhage (SAH)