Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of a combination of omeprazole and high-dose proton pump inhibitors on the treatment of patients with liver cirrhosis complicated with upper gastrointestinal hemorrhage

Qiang Chi¹ , Zhiqiang Lv², Wenjuan Song³

¹Health Management Center, Qingdao Chengyang District People’s Hospital, Chengyang, Qingdao; ²Qingdao Chengyang District People’s Hospital, Chengyang, Qingdao; ³Thoracic and Cardiovascular Surgery, Qingdao Chengyang District People’s Hospital, Chengyang, Qingdao, China.

For correspondence:- Qiang Chi Email: xianweimi01132@163.com Tel:+8617806232677

Accepted: 23 September 2021 Published: 31 October 2021

Citation: Chi Q, Lv Z, Song W. Effect of a combination of omeprazole and high-dose proton pump inhibitors on the treatment of patients with liver cirrhosis complicated with upper gastrointestinal hemorrhage. Trop J Pharm Res 2021; 20(10):2143-2148 doi: 10.4314/tjpr.v20i10.18

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To determine the effect of a combination of omeprazole and high-dose proton pump inhibitor (PPI) on the treatment of patients with liver cirrhosis complicated with upper gastrointestinal hemorrhage.

Methods: A total of 100 patients with liver cirrhosis and upper gastrointestinal hemorrhage who were admitted to Qingdao Chengyang District People’s Hospital from January 2019 to September 2020 were matched and randomly assigned to a control group and a study group. Patients in both groups received a high-dose PPI treatment, while those in the study group were given omeprazole in addition to high-dose PPI. Total treatment effectiveness, incidence of adverse reactions, bleeding volume, hemostasis time, liver function after treatment, Quality of Life Index (QLI) scores, Visual Analogue Scale (VAS) scores, and bleeding (%) at 1, 2 and 4 weeks after treatment were compared for the two groups of patients.

Results: Omeprazole-PPI combination produced a much more favorable outcome than treatment with only high-dose PPI, in terms of effectiveness, QLI scores and liver function (p < 0.05). The study group had significantly lower incidence of adverse reactions, bleeding volume, VAS scores, and degree of bleeding at 1, 2 and 4 weeks after treatment, as well as shorter hemostasis time, than the control group (p < 0.05).

Conclusion: A combination treatment of omeprazole and high-dose PPI produces better therapeutic effect than high-dose PPI alone, in patients with liver cirrhosis and upper gastrointestinal hemorrhage.

Keywords: Omeprazole, High-dose proton pump inhibitor, Liver cirrhosis, Upper gastrointestinal hemorrhage