Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Efficacy of normodyne-magnesium sulfate combination treatment on pregnancy-induced hypertension, and its effect on VEGF and Flt-1 levels

Xiaoyan Diao¹ , Kun Ding¹, Xuemei Ma²

¹Obstetrics Department, Maternal and Child Health Hospital of Xinjiang Uygur Autonomous Region, Xinjiang 8300000; ²Department of Gynecology, Urumqi Youai Hospital, Urumqi 831400, PR China.

For correspondence:-

Accepted: 21 September 2021 Published: 31 October 2021

Citation: Diao X, Ding K, Ma X. Efficacy of normodyne-magnesium sulfate combination treatment on pregnancy-induced hypertension, and its effect on VEGF and Flt-1 levels. Trop J Pharm Res 2021; 20(10):2155-2161 doi: 10.4314/tjpr.v20i10.20

© 2021 The authors.
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Abstract

Purpose: To investigate the efficacy of the combined use of normodyne and magnesium sulfate in the treatment of pregnancy-induced hypertension, and its effect on vascular endothelial growth factor (VEGF) and factor receptor-1 (Flt-1) levels in serum.

Methods: A total of 100 patients with pregnancy-induced hypertension attending Maternal and Child Health Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, China, were categorized as Group A, and then further subdivided into control sub-group (who were treated with magnesium sulfate only) and study sub-group (treated with magnesium sulfate plus normodyne). Furthermore, 100 healthy pregnant women attending the hospital for prenatal examination during the same period were categorized as Group B. Serum expressions of VEGF and Flt-1 in all patients were determined and compared. The therapeutic effect, adverse reactions, adverse pregnancy outcomes, blood pressure before and after treatment, 24 h proteinuria, and serum expression levels of VEGF and Flt-1 in the study and control groups were determined and compared.

Results: Serum VEGF levels in patients with pregnancy-mediated hypertension were significantly lower than those of healthy pregnant women, and Flt-1 was raised in healthy pregnant women (p < 0.05). In the study group, treatment was markedly more effective, and the degree of amelioration of blood pressure, 24 h proteinuria, serum VEGF, and Flt-1 were significantly higher than for control sub-group. There were lower adverse pregnancy outcomes in study sub-group than in control (p < 0.05).

Conclusion: The combination of magnesium sulfate and normodyne produces greater clinical efficacy in the treatment of patients with pregnancy-induced hypertension than magnesium sulfate alone, and also shows a high safety profile.

Keywords: Normodyne, Magnesium sulfate, Pregnancy-induced hypertension, VEGF, Flt-1