Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Combined effect of ultrasound-guided percutaneous abdominal paracentesis drainage and ulinastatin on severe acute pancreatitis

Chuanmin Liu¹, Fei Yuan², Baowei Wang³, Xuezhen Wang⁴

¹Intensive Care Unit, Jiaozhou Central Hospital, Qingdao; ²Department of Internal Medicine, Qingdao Integrated Traditional Chinese and Western Medicine Hospital, Qingdao, Shandong; ³Department of Emergency Medicine, 4ICU, Jiaozhou People's Hospital, Jiaozhou, Qingdao, China.

For correspondence:- Xuezhen Wang Email: gongliao33282583@163.com

Accepted: gongliao33282583@163.com Published: 31 October 2021

Citation: Liu C, Yuan F, Wang B, Wang X. Combined effect of ultrasound-guided percutaneous abdominal paracentesis drainage and ulinastatin on severe acute pancreatitis. Trop J Pharm Res 2021; 20(10):2187-2192 doi: 10.4314/tjpr.v20i10.24

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To study the clinical effect of a combination of ultrasound-guided percutaneous abdominal paracentesis drainage (APD) and ulinastatin on severe acute pancreatitis (AP).

Methods: A total of 94 patients with severe AP in Intensive Care Unit, Jiaozhou Central Hospital, Qingdao, from December 2017 to December 2018 were selected as the research subjects. They were divided into control and study groups, with 47 patients in each group. Patients in the control group underwent laparotomy drainage, while patients in the study group underwent ultrasound-guided percutaneous APD. Patients in both groups received ulinastatin perfusion. Subsequently, clinical effects and other relevant indicators were determined.

Results: Overall response was significantly higher in the study group than in the control group (p < 0.05). The times taken for disappearance of postoperative symptoms, normalization of serum amylase level, and hospitalization were significantly shorter in the study group than in the control group (p < 0.05). For every indicator, the study group exhibited more benefits after than before treatment; however, post-treatment levels of blood glucose, hemodiastase and urinary amylase were better than those in the control group (p < 0.05). Incidence of postoperative complications was lower in the study group than in control group (p < 0.05).

Conclusion: The combination of ultrasound-guided percutaneous APD with ulinastatin produces marked beneficial effects on severe AP patients. It facilitates the remission of adverse symptoms, and enhances normalization of indicator levels. Moreover, it displays low incidence of complications, better prognosis and recovery, and absence of post-operation infections.

Keywords: Ultrasound-guided, Percutaneous abdominal paracentesis drainage, Ulinastatin, Severe acute pancreatitis