Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Antiglycation and hypolipidemic effects of polyphenols from Zingiber officinale Roscoe (Zingiberaceae) in streptozotocin-induced diabetic rats

Mutiu I Kazeem^1,2, Musbau A Akanji², Musa T Yakubu², Anofi OT Ashafa¹

¹Phytomedicine and Phytopharmacology Research Group, Department of Plant Sciences, University of the Free State, Qwaqwa Campus, Phuthaditjhaba 9866, South Africa; ²Department of Biochemistry, University of Ilorin, PMB 1515, Ilorin, Nigeria.

For correspondence:- Anofi Ashafa Email: ashafaaot@qwa.ufs.ac.za Tel:+27587185134

Received: 26 August 2014 Revised: 6 December 2014 Published: 30 January 2015

Citation: Kazeem MI, Akanji MA, Yakubu MT, Ashafa AO. Antiglycation and hypolipidemic effects of polyphenols from Zingiber officinale Roscoe (Zingiberaceae) in streptozotocin-induced diabetic rats. Trop J Pharm Res 2015; 14(1):55-61 doi: 10.4314/tjpr.v13i8.9

© 2015 The authors.
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Abstract

Purpose:To evaluate the antiglycation and hypolipidemic potential of polyphenols from Zingiber officinale in streptozotocin-induced diabetic rats.

Methods:Diabetes was induced in male Wistar rats by single intraperitoneal injection of 50 mg/kg body weight (bw) of streptozotocin. This was followed by oral administration of 500 mg/kg each of free and bound polyphenol extracts of Z. officinale to the rats daily for 42 days. Distilled water and glibenclamide (5 mg/kg) were used as normal and positive controls, respectively.

Results:Significant increases (p < 0.05) in blood glucose level (369.26 mg/dL), serum advanced glycation end-products (AGEs) (6.80 µg/mL), lipid profile and atherogenic indices, with decrease in high density lipoprotein cholesterol (HDL-C) (15.55 mg/dL) were observed in diabetic rats compared to control. Free polyphenol extracts of Z. officinale significantly reduced (p < 0.05) blood glucose (147.96 mg/dL), serum AGEs (1.98 µg/mL), lipid profile and atherogenic indices while it significantly increased HDL-C (23.28 mg/dL). However, bound polyphenol extract did not cause any significant change in the lipid profile of the diabetic rats except for LDL-C.

Conclusion:This study indicates that free and bound polyphenols from Z. officinale can ameliorate diabetes as well as its complications, and its effect is comparable to that of the standard drug, glibenclamide.

Keywords: Zingiber officinale, Diabetes, Lipid profile, Atherogenic index, Polyphenol, Glycation, Streptozotocin