Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of budesonide aerosol inhalation on postoperative complications and foreign body sensation in the throat of goiter resection patients

Yijun Chen¹ , Guolie Zhang¹, Yuanmei Lin¹, Guoliang Zhang¹, Lifen Lin², Huiying Yao³, Jinfan Zhang⁴

¹First Department of Thyroid Surgery, The Affiliated Hospital of Putian University, Putian 351100, Fujian, China; ²Operation Room, The Affiliated Hospital of Putian University, Putian 351100, Fujian, China; ³Neurology Department, The Affiliated Hospital of Putian University, Putian 351100, Fujian, China; ⁴Department of Breast Surgery, The Affiliated Hospital of Putian University, Putian 351100, Fujian, China.

For correspondence:- Yijun Chen Email: chenyijun1987@126.com Tel:+865942293910

Accepted: 6 October 2021 Published: 30 November 2021

Citation: Chen Y, Zhang G, Lin Y, Zhang G, Lin L, Yao H, et al. Effect of budesonide aerosol inhalation on postoperative complications and foreign body sensation in the throat of goiter resection patients. Trop J Pharm Res 2021; 20(11):2395-2400 doi: 10.4314/tjpr.v20i11.23

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To study the effect of budesonide aerosol inhalation on postoperative complications and foreign-body sensation in the throat of patients who underwent goiter resection.

Methods: One hundred and twenty patients who underwent goiter resection at The Affiliated Hospital of Putian University (Fujian, China) from January 2019 to January 2020 were included in the study, and then equally and randomly assigned to groups A and B. During the perioperative period, group A patients were given budesonide aerosol inhalation, while group B patients received aerosol inhalation of equivalent volume of normal salineectively. Postoperative complication rate (CR), complication pain scores, scores on mucosal response in the throat, and scores on foreign body sensation in the throat were determined for both groups.

Results: Postoperative complications in patients were hoarseness, sore throat and cough. Group A had significantly lower postoperative CR, lower complication pain scores, lower scores on mucosal response in the throat, and lower scores on foreign body sensation in the throat, when compared to group B (p < 0.001).

Conclusion: Budesonide aerosol inhalation in patients who underwent goiter resection is effective in relieving throat injury from general anesthesia, minimizing likelihood of postoperative complications, and easing foreign-body sensation in the throat. Thus, this strategy may be suitable for the management of postoperative complications.

Keywords: Budesonide, Aerosol inhalation, Thyroid postoperative complications