Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Levels of IL-17 and IL-35 in Chinese women as biomarkers of preeclampsia, and their pharmacological association with Traditional Chinese Medicine

Lina Wang¹, Yu Liu², Shude Liu³, Caiqin Ling¹, Kui Li⁴, Qizhi Xiao⁵, Xiong Liang¹

¹Department of Obstetrics, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), Guangdong Province 519000, China; ²Department of Obstetrics, Zhuhai Woman and Children’s Hospital, Guangdong Province 519000, China; ³Department of Obstetrics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China; ⁴Department of Translational Medicine Research Institute, Guangzhou Huayin, Medical Laboratory Center Ltd, Guangzhou, Guangdong Province 510000, China; ⁵Laboratory Medicine, Zhuhai Woman and Children’s Hospital, Zhuhai, Guangdong Province 519000, China.

For correspondence:- Xiong Liang Email: xiongiang369@hotmail.com Tel:+867562222569

Accepted: 23 October 2021 Published: 31 December 2021

Citation: Wang L, Liu Y, Liu S, Ling C, Li K, Xiao Q, et al. Levels of IL-17 and IL-35 in Chinese women as biomarkers of preeclampsia, and their pharmacological association with Traditional Chinese Medicine. Trop J Pharm Res 2021; 20(12):2573-2579 doi: 10.4314/tjpr.v20i12.17

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To determine the serum levels of IL-17 and IL-35 in preeclamptic Chinese women, and their pharmacological association with Traditional Chinese Medicine (TCM) compounds.

Methods: In this study, 60 preeclamptic and 60 healthy pregnant Chinese women comprised the study and control groups, respectively. The serum levels of IL-17 and IL-35 were determined using the ELISA technique. Moreover, the anti-inflammatory effects of 5 TCM compounds were determined with respect to their inhibitory potential against IL-10 and IL-35 in RAW 264.7 cells.

Results: There were statistically significant differences in mean serum levels of IL-17 and IL-35 between preeclamptic patients and control patients (p < 0.05). Furthermore, the serum levels of the two cytokines were significantly higher in patients with severe preeclampsia than in patients with mild preeclampsia (p < 0.05). Significant positive correlations were observed between systolic blood pressure of patients and levels of IL-17 and IL-35. The 5 TCM compounds showed good inhibitory potential against IL-17 and IL-35, when compared to the reference drug and positive control (p < 0.05).

Conclusion: IL-17 and IL-35 are useful inflammatory biomarkers for preeclampsia in Chinese women, and can potentially be used to assess the severity of the disease. In addition, TCM compounds which inhibit IL-17 and IL-35 may be useful therapeutic agents for controlling preeclampsia.

Keywords: Preeclampsia, IL-17, IL-35, Inflammatory biomarker, Traditional Chinese Medicine