Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Comparative study on the clinical efficacy of clopidogrel and ticagrelor in patients with stent-assisted aneurysm embolization

Xiao Chen, Weidong Xu, Lei Zhao, Xiaohui Yue, Yongjun Zhu, Endong Song, Zhiqiang Liu

Neurosurgery Department, Rushan People's Hospital, Rushan City, Shandong Province, China;

For correspondence:- Zhiqiang Liu Email: friendlei@163.com

Accepted: 29 November 2021 Published: 31 December 2021

Citation: Chen X, Xu W, Zhao L, Yue X, Zhu Y, Song E, et al. Comparative study on the clinical efficacy of clopidogrel and ticagrelor in patients with stent-assisted aneurysm embolization. Trop J Pharm Res 2021; 20(12):2605-2610 doi: 10.4314/tjpr.v20i12.21

© 2021 The authors.
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Abstract

Purpose: To investigate the clinical efficacy and safety of clopidogrel and ticagrelor in stent-assisted aneurysm embolization.

Methods: One hundred and ten patients with stent-assisted embolization of intracranial aneurysms were randomized into control and study groups (CG and SG). CG received clopidogrel plus aspirin while SG received ticagrelor plus aspirin Their clinical efficacies were compared.

Results: The maximum platelet aggregation rate (MPAR) and P2Y12 reaction unit (PRU) at 24 h and 1 week after surgery in SG were significantly lower compared with CG (p < 0.05). Arachidonic acid (AA) inhibition rate in SG was slightly higher than that in CG (p > 0.05), while the adenosine diphosphate (ADP) inhibition rate in SG was higher compared with CG (p < 0.05). The inflammatory factor levels were significantly lower in SG than in CG (p < 0.05). The incidence of clinical endpoint events within one year after surgery in SG was notably lower compared with CG (p < 0.05).

Conclusion: For patients with stent-assisted aneurysm embolization, ticagrelor has a better inhibitory effect on platelet aggregation and a lower incidence of platelet resistance than those of clopidogrel. In addition, ticagrelor inhibits the occurrence of clinical endpoint events and has high medication safety.

Keywords: Clopidogrel, Ticagrelor, Stent implantation, Intracranial aneurysms