Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Treatment effectiveness of zedoary turmeric oil on viral encephalitis in children, and its effect on serum and cerebrospinal levels of NSE and S100B

Zili Hou¹, Bing Han², Guosheng Xie², Cuilin Zhang², Fang Wang²

¹Department of Pharmacy, Xingtai People's Hospital, Xingtai City 054001, Hebei Province, China; ²Department of Paediatrics, Xingtai People's Hospital, Xingtai City 054001, Hebei Province, China.

For correspondence:- Fang Wang Email: ff5p1b@163.com Tel:+86 03193286439

Accepted: 26 November 2021 Published: 31 December 2021

Citation: Hou Z, Han B, Xie G, Zhang C, Wang F. Treatment effectiveness of zedoary turmeric oil on viral encephalitis in children, and its effect on serum and cerebrospinal levels of NSE and S100B. Trop J Pharm Res 2021; 20(12):2625-2631 doi: 10.4314/tjpr.v20i12.24

© 2021 The authors.
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Abstract

Purpose: To investigate the effectiveness of the combination of zedoary turmeric oil, ganciclovir and interferon in the treatment of children with viral encephalitis, and its effect on neuron-specific enolase (NSE) and S100B.

Methods: One hundred (100) children with viral encephalitis were selected and assigned to control group (n = 50) and study group (n = 50). Children in control group received ganciclovir and interferon, while those in the study group received ganciclovir, interferon and zedoary turmeric oil. The treatment effectiveness, mitigation of symptoms, incidence of adverse reactions, and changes in levels of NSE and S100B in serum and cerebrospinal fluid (CSF) after treatment were analyzed for the two groups of children.

Results: Treatment effectiveness for the study group (98 %) was significantly higher than for the control group (84 %, p < 0.05). The time taken for the mitigation of clinical symptoms was markedly shorter in the study group than in control. There was a lower incidence of adverse reactions in children in the study group (2 %) than in controls (28 %). Serum NSE level (32.65 ± 13.18 ug/mL) and serum S100B level (5.56 ± 4.01 ug/mL) in the study group were significantly lower (p < 0.05) than the corresponding control levels (38.95 ± 11.95 ug/mL for NSE; and 8.18 ± 4.32 ug/ml for S100B).

Conclusion: The use of a combination of ganciclovir, interferon and zedoary turmeric oil treatment improves therapeutic effect in children with viral encephalitis. Therefore, the combination treatment merits clinical promotion and application.

Keywords: Zedoary turmeric oil, Viral encephalitis, NSE, S100B