Safura Binti Mohd Mohari1,
Nattika Nimmano1,2 
For correspondence:- Nattika Nimmano Email: nattika.n@pharm.chula.ac.th Tel:+66892013131
Accepted: 3 January 2022 Published: 31 January 2022
Citation: Mohari SB, Nimmano N. Comparison between air-jet and vibrating-mesh nebulizers in the delivery of nebulized salbutamol sulfate determined using an abbreviated impactor. Trop J Pharm Res 2022; 21(1):1-6 doi: 10.4314/tjpr.v21i1.1
© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the aerodynamic properties of nebulized droplets from nebulizers for delivery of salbutamol sulfate.
Methods: Drug deposits were collected from fast screening impactor (FSI). Parameters of aerosolization such as dryness time and salbutamol sulfate characteristics were determined using chilled FSI at a flow velocity of 15 L/min, with salbutamol sulfate solution nebulized to dryness. An optimized HPLC procedure was used to analyze the deposited salbutamol sulfate across the FSI. Parameters comprising mass balance, FPD and FPF were determined.
Results: Statistical analysis showed that the performance of vibrating-mesh was more efficient than that of air-jet device, as depicted in significantly higher values FPF of aerosolized droplets (60 and 40 %, respectively; p < 0.05).
Conclusion: The performance of aerosol generation using vibrating-mesh was more superior to that of air-jet nebulizer. However, there is need for further investigations on various physicochemical properties of nebulizer fluid as well as improvement in percentage FPF.
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