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Original Research Article | OPEN ACCESS

Effect of bone marrow mesenchymal stem cells on tissue reconstruction and angiogenesis following fat transplantation

Yao Shi1 , Li Shi2

1Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China; 2Department of Orthopaedic Surgery, The First Affiliate Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, PR China.

For correspondence:-  Yao Shi   Email: b7pcqx@163.com

Accepted: 7 January 2022        Published: 31 January 2022

Citation: Shi Y, Shi L. Effect of bone marrow mesenchymal stem cells on tissue reconstruction and angiogenesis following fat transplantation. Trop J Pharm Res 2022; 21(1):73-78 doi: 10.4314/tjpr.v21i1.12

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effect of bone marrow mesenchymal stem cells (BMSCs) on tissue reconstruction and microvascular formation after fat transplantation.
Methods: Adipose tissue from male BALB/C nude mice were used to extract and culture BMSCs. Eighty mice were assigned to control and study groups. Control mice were injected with 0.3 g adipose tissue in normal saline, while the study group was injected with 0.3 g adipose tissue containing 5 × 105 mouse BMSCs. Micro-vessel count was determined by CD31 antibody staining, while VEGF protein expression was assayed by Western blotting.
Results: At each time point, the micro-vessel count of adipose tissue was significantly higher in the study group than in controls (p < 0.05). At 12 weeks, VEGF protein in adipose tissue of mice was significantly higher in the study mice than in control mice (p < 0.05).
Conclusion: BMSCs enhance adipose tissue reconstruction and induce adipose tissue microvascular formation through up-regulation of the protein expression of VEGF.

Keywords: Bone marrow mesenchymal stem cells, Fat transplant, Tissue reconstruction, Angiogenesis

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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