Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of combined Qilin pill and estradiol valerate tablets on irregular menstruation in patients, and their serum levels of estradiol, progesterone and luteinizing hormone

Yuhe Zhou¹, Hongbo Ma² , Ting Liu³

¹College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine; ²Shandong Provincial Hospital affiliated to Shandong First Medical University, Shandong; ³The People’s Hospital of Huaiyin. Jinan, China.

For correspondence:- Hongbo Ma Email: juwei46755971@163.com

Accepted: 31 December 2021 Published: 31 January 2022

Citation: Zhou Y, Ma H, Liu T. Effect of combined Qilin pill and estradiol valerate tablets on irregular menstruation in patients, and their serum levels of estradiol, progesterone and luteinizing hormone. Trop J Pharm Res 2022; 21(1):201-206 doi: 10.4314/tjpr.v21i1.29

© 2022 The authors.
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Abstract

Purpose: To determine the clinical effect of combined treatment with Qilin pill and estradiol valerate tablets on irregular menstruation patients, and its impact on serum levels of estradiol (E2), progesterone (P) and luteinizing hormone (LH).

Methods: A total of 120 irregular menstruation patients admitted to our hospital from January 2019 to January 2020 were randomly divided into group A (n=60) and group B (n = 60). Group B was treated with estradiol valerate tablets only, while group A was given Qilin pill, in addition to estradiol tablets. Treatment effectiveness, time taken to achieve normal menstruation, ovulation rate, hormonal levels, endometrial thickness, and clinical symptom scores were compared between the two groups of patients.

Results: There was higher treatment effectiveness in group A than in group B

(p <0.05). The time taken to return to normal menstruation was significantly shorter in group A than in group B (p < 0.001). Group A patients had markedly higher ovulation rate, higher endometrial thickness, and more favorable hormonal levels than patients in group B (p < 0.05). Moreover, post-treatment clinical symptom score of group A was superior to that of group B (p <0.001).

Conclusion: The combined use of Qilin pills and estradiol valerate tablets mitigates clinical symptoms in patients with irregular menstruation, increases their ovulation rate and hormonal levels, and enhances return to normal menstruation. Therefore, the combination treatment appears to be suitable for the management of menstrual issues.

Keywords: Qilin pills, Estradiol valerate tablets, Irregular menstruation