Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of combination of intravenous general anesthesia with propofol and fentanyl on surgery for aortic dissection repair in patients, and its influence on respiratory and circulatory functions

Zhuoya Bai¹, Yuhua Kong¹, Lin Chen², Lingling Wang³

¹Department of Anesthesiology, Xiangyang No.1 People's Hospital Hubei University of Medicine, Xiangyang, 441000, Hubei Province, China; ²Department of Urinary Surgery, Xiangyang No.1 People's Hospital Hubei University of Medicine, Xiangyang, 441000, Hubei Province, China; ³Department of Cardiology, Xiangyang No.1 People's Hospital Hubei University of Medicine, Xiangyang, 441000, Hubei Province, China.

For correspondence:- Lingling Wang Email: wll13871681119@163.com Tel:+8613871681119

Accepted: 14 March 2022 Published: 30 April 2022

Citation: Bai Z, Kong Y, Chen L, Wang L. Effect of combination of intravenous general anesthesia with propofol and fentanyl on surgery for aortic dissection repair in patients, and its influence on respiratory and circulatory functions. Trop J Pharm Res 2022; 21(4):847-852 doi: 10.4314/tjpr.v21i4.23

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effect of application of propofol in combination with fentanyl intravenous anesthesia in interventional surgery for aortic dissection repair, and its influence on respiratory and circulatory functions in patients.

Methods: 100 patients undergoing interventional surgery for aortic dissection repair in Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang. China from November 2018 to May 2020 were assigned equally to control group (CG) and study group (SG). CG received general anesthesia with propofol, while those in SG received combined intravenous general anesthesia with propofol and fentanyl. Time of anesthesia onset, postoperative awakening time, extubation time, respiratory function indicators and circulatory function indicators before operation (T0), and at intraoperative 1 h (T1), intraoperative 2 h (T2) and postoperative 2 h (T3); as well as postoperative VAS pain scores, and Ramsay sedation scores were determined and compared.

Results: Compared with CG, SG had shorter anesthesia onset, shorter postoperative awakening and extubation times, and lower postoperative VAS pain and Ramsay sedation scores (p < 0.05). At T1, T2 and T3, indicators of respiratory and circulatory functions were better in SG than in CG (p > 0.05).

Conclusion: Combined intravenous general anesthesia using propofol and fentanyl was more effective in interventional surgery for repair of aortic dissection, and it enhanced respiratory and circulatory functions in the patients.

Keywords: Combined intravenous general anesthesia, propofol, fentanyl, interventional surgery, aortic dissection, respiratory function, circulatory function