Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of cognitive rehabilitation training combined with butylphthalide soft capsules and ginkgo-leaf tablets on patients with mild Alzheimer's disease

Yuanyuan Zhong¹, Jiaoping Chen²

¹Ward 2, Department of Internal Medicine, Zhuji Central Hospital of Zhejiang Province, China; ²Department of Internal Neurology, Zhuji Traditional Chinese Medical Hospital of Zhejiang Province, Shaoxing 311800, China.

For correspondence:- Jiaoping Chen Email: ppnh55@163.com

Accepted: 27 March 2022 Published: 30 April 2022

Citation: Zhong Y, Chen J. Effect of cognitive rehabilitation training combined with butylphthalide soft capsules and ginkgo-leaf tablets on patients with mild Alzheimer's disease. Trop J Pharm Res 2022; 21(4):887-892 doi: 10.4314/tjpr.v21i4.28

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To study the impact of a combination of cognitive rehabilitation training, butylphthalide soft capsules and ginkgo-leaf tablets on patients with mild Alzheimer’s disease (AD).

Methods: One hundred and twenty-eight (128) mild AD patients were randomly assigned to medication treatment group (MT group, n = 64) and joint training group (JT group, n = 64). Both groups were treated with butylphthalide soft capsules and ginkgo-leaf tablets, while the JT group additionally received cognitive rehabilitation training. Therapeutic effects and adverse drug reactionsin the two groups were assessed.

Results: Total effectiveness was significantly higher in JT patients (84.38 %) than in MT patients (60.94 %; χ² = 8.9320). After treatment, Mini-Mental State Exam (MMSE), Activity of Daily Living (ADL) and ADAS-cog scores in the JT group were significantly better than those in the MT group, (p < 0.05). There were significantly lower plasma NO, serum VEGF and MDA levels in JT patients than in MT patients. CRP and Hcy levels were markedly lower in JT than in MT patients. The incidence of adverse reactions in both groups was comparable (p > 0.05).

Conclusion: Rehabilitation training in combination with butylphthalide soft capsule and ginkgo-leaf tablets produce significant therapeutic impact on mild AD patients. The combination therapy delays cognitive decline and memory loss in AD patients, improves their serological indicators, and lowers the incidence of adverse reactions.

Keywords: Cognitive rehabilitation training, Butylphthalide soft capsules, Ginkgo-leaf tablets, Mild Alzheimer disease