Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of chloroprocaine combined with morphine on analgesia, adverse reactions and dynamic changes in inflammation in patients receiving TURP

Lin Zhu, Peili Lin, Xulei Lv, Jingyu Zhao, Mengmeng Li

Department of Anesthesiology, the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100048, China;

For correspondence:- Mengmeng Li Email: mmli304@163.com Tel:+861066848088

Accepted: 29 March 2022 Published: 30 April 2022

Citation: Zhu L, Lin P, Lv X, Zhao J, Li M. Effect of chloroprocaine combined with morphine on analgesia, adverse reactions and dynamic changes in inflammation in patients receiving TURP. Trop J Pharm Res 2022; 21(4):893-898 doi: 10.4314/tjpr.v21i4.29

© 2022 The authors.
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Abstract

Purpose: To investigate the influence of chloroprocaine combined with morphine on the analgesic effects, adverse reactions and inflammation factors in patients receiving transurethral resection of the prostate (TURP).

Methods: A total of 80 patients with benign prostatic hyperplasia (BPH) in the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100048, China, were divided into morphine group and combination-therapy group (morphine combined with chloroprocaine). Pain index, changes in inflammatory factors and incidence of adverse reactions in the two groups of patients were assessed.

Results: The morphine group and combination-therapy group showed basic profile prior to the treatments. Visual Analogue Scale (VAS) scores before operation and 6 h after operation in the morphine group were similar to those in the combination-therapy group, but the scores at 12, 24 and 48 h after operation in the combination-therapy group were significantly lower than those in the morphine group. Similarly, the combination-therapy group showed lower levels of substance P (SP) and bradykinin (BK) at 12, 24 and 48 h after operation than the morphine group (p < 0.05). Both groups exhibited similar levels of serum inflammatory factors before the operation, but the levels decreased in the combination-therapy group when compared with those in the morphine group after operation (p < 0.05). The combination-therapy group also showed a lower incidence of adverse reactions than the morphine group.

Conclusion: Chloroprocaine combined with morphine effectively ameliorates postoperative pain, lowers secretion of tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10), and decreases the incidence of postoperative adverse reactions, thus affording a high level of safety after operation.

Keywords: Benign prostatic hyperplasia, Morphine, Chloroprocaine, Analgesia, Inflammation, Adverse reactions