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Original Research Article | OPEN ACCESS

Effect of beraprost sodium on renal function and p38MAPK signaling pathway in rats with diabetic nephropathy

Liangxiao Xie1, Jiajia Dong1, Jinzhi Wu1, Changshun Wei1, Kezhen Xu2, Pengbin Lai1 , Xiaoyun Zha1

1Department of Endocrinology and Metabolism, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian Province, China; 2Department of Pharmacy, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian Province, China.

For correspondence:-  Pengbin Lai   Email: ptrx35@163.com   Tel:+865962081196

Accepted: 21 April 2022        Published: 31 May 2022

Citation: Xie L, Dong J, Wu J, Wei C, Xu K, Lai P, et al. Effect of beraprost sodium on renal function and p38MAPK signaling pathway in rats with diabetic nephropathy. Trop J Pharm Res 2022; 21(5):939-942 doi: 10.4314/tjpr.v21i5.5

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effect of beraprost sodium (BPS) on renal function and P38MAPK pathway in diabetic nephropathy (DN) rats.
Methods: Sprague Dawley (SD) rats (n = 30) were randomly divided into three groups, viz, normal control (NC), diabetic nephropathy (DN) and beraprost sodium (BPS). Creatinine (Cr), blood urea nitrogen (BUN) and fasting blood glucose (FBG), were determined by Hitachi 7020 automatic biochemical analyzer, while low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) and total cholesterol (TC) were measured by Olympus 400 automatic biochemical analyzer. Western blot analysis was performed to examine protein expression. Interleukin-6 (IL-6), hs-CRP, and TNF-α levels were evaluated using enzyme linked immunosorbent assay (ELISA).
Results: After 8 weeks of treatment, renal function indices (urine output, KW/BW, UAlb/24 h, Cr and BUN), blood lipid indices (FBG, LDL-C, TG and TC) and inflammatory factors levels (IL-6, hs-CRP and TNF-α) in DN group were higher than NC group (p < 0.05). In BPS group, renal function and blood lipid indices and inflammatory factor levels decreased when compared to DN group (p < 0.05). Furthermore, BPS inhibited the protein expression of p-P38MAPK, TGF-β1 and COX-2.
Conclusion: Beraprost sodium improves renal function in DN rats by inhibiting P38MAPK signaling pathway.

Keywords: Renal function, Diabetic nephropathy, Inflammatory factors, Beraprost sodium, P38MAPK signaling pathway

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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