Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Efficacy and safety of post-auricular injection of methylprednisolone sodium succinate and lidocaine in the treatment of acute tinnitus, and its effect on sleep quality

Bijun Liang¹, Xiaohua Feng², Rui Deng¹, Youli Liu¹, Ying He¹, Xiwu Zhang³

¹Department of Otolaryngology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China; ²Department of Otolaryngology, General Hospital of Southern Theatre Command, Guangzhou, Guangdong, China; ³Department of Neurosurgery, General Hospital of Southern Theatre Command, Guangzhou, Guangdong, China.

For correspondence:- Xiwu Zhang Email: zihuangguansb@163.com Tel:+8613538989598

Accepted: 21 April 2022 Published: 31 May 2022

Citation: Liang B, Feng X, Deng R, Liu Y, He Y, Zhang X. Efficacy and safety of post-auricular injection of methylprednisolone sodium succinate and lidocaine in the treatment of acute tinnitus, and its effect on sleep quality. Trop J Pharm Res 2022; 21(5):1079-1085 doi: 10.4314/tjpr.v21i5.24

© 2022 The authors.
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Abstract

Purpose: To study the efficacy and safety of post-auricular injection of methylprednisolone sodium succinate plus lidocaine in the treatment of acute tinnitus, and its effect on sleep quality.

Methods: Eighty acute tinnitus patients admitted to Nanfang Hospital, Southern Medical University, Guangzhou, China from January 2020 to June 2021, served as subjects for this retrospective analysis. The patients were equally assigned to a reference group given postauricular injection of lidocaine, and a research group treated with post-auricular injection of methylprednisolone sodium succinate in combination with lidocaine. Treatment efficacy values in the two groups of patients were determined and compared.

Results: Total treatment effectiveness values in patients in the research group after one course of treatment, and at three months post-treatment, were significantly higher than the corresponding values in the reference group (p < 0.05). After treatment, the two groups had markedly improved Tinnitus Handicap Inventory (THI) scores, although patients in the research group had lower scores than those in reference group (p < 0.05). There were significant decreases in post-treatment pure tone threshold and Pittsburgh sleep quality index (PSQI) in the two groups of patients, with lower values in the research group than in the reference group (p < 0.05). There were no obvious adverse drug reactions during treatment and during 3-month follow-up period.

Conclusion: Post-auricular injection of methylprednisolone sodium succinate and lidocaine effectively improved the clinical efficacy and the sleep quality of acute tinnitus patients. It is a simple and highly safe operation which merits clinical application.

Keywords: Acute tinnitus, Methylprednisolone, Lidocaine, Sleep quality, Clinical efficacy