Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of non-invasive ventilator in combination with tiotropium bromide on pulmonary function and sleep quality of patients with chronic obstructive pulmonary disease complicated with obstructive sleep apnea-hypopnea syndrome

Dongli Liu¹, Xiaolong He², Jianquan Gao¹, Qiangqiang Luan¹, Yanling Du¹

¹Department of Respiratory and Critical Medicine, Yan'an Traditional Chinese Medicine Hospital, Yan’an 716000, Shanxi Province, China; ²Department of ICU Medicine, Yan'an Traditional Chinese Medicine Hospital, Yan'an 716000, Shanxi Province, China.

For correspondence:- Yanling Du Email: djhb77@163.com Tel:+8613892163668

Accepted: 2 May 2022 Published: 31 May 2022

Citation: Liu D, He X, Gao J, Luan Q, Du Y. Effect of non-invasive ventilator in combination with tiotropium bromide on pulmonary function and sleep quality of patients with chronic obstructive pulmonary disease complicated with obstructive sleep apnea-hypopnea syndrome. Trop J Pharm Res 2022; 21(5):1087-1093 doi: 10.4314/tjpr.v21i5.25

© 2022 The authors.
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Abstract

Purpose: To study the influence of non-invasive ventilator and tiotropium bromide on pulmonary function and sleep quality of patients with chronic obstructive pulmonary disease (COPD) combined with obstructive sleep apnea-hypopnea syndrome (OSAHS).

Methods: One hundred and twenty patients with COPD-OSAHS were selected and randomly assigned to control group (CG) and treatment group (TG), with 60 subjects in each group. Non-invasive ventilator therapy was used in both groups, based on conventional therapy, while tiotropium bromide was added in TG. Treatment effectiveness in the two groups was evaluated and compared.

Results: Total effectiveness was significantly higher in TG than in CG. Post-therapy arterial oxygen saturation (SaO₂) and oxygen partial pressure (PaO₂) were increased, while partial pressure of carbon dioxide (PaCO₂) and lactic acid (Lac) were decreased in both groups (p < 0.05). Post-treatment values of indices of lung function, viz, forced expiratory volume (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio were higher than the corresponding pre-treatment levels, and also values were significantly higher in TG than in CG (p < 0.05). Average sleep time, apnea and hypopnea index (AHI) and mechanical ventilation time of TG were less than those of CG. There were lower levels of C-reactive protein (CRP), procalcitonin (PCT) and interleukin-17 (IL-17) in TG than in CG. During the treatment, no obvious adverse reaction was seen in both groups.

Conclusion: Non-invasive ventilator, in combination with tiotropium bromide, is more effective in the treatment of COPD-OSAHS than the use of non-invasive ventilator alone. However, further clinical trials are required before its adoption in clinical practice.

Keywords: Chronic obstructive pulmonary disease (COPD), Obstructive sleep apnea-hypopnea syndrome (OSAHS), Tiotropium bromide, Noninvasive ventilator