Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Diagnostic efficacy of two-dimensional echocardiography combined with coronary angiogram in patients with acute myocardial infarction, and the effectiveness of atorvastatin

Lijuan Liao¹, Wenwu Huang², Chun Xiong³

¹B Ultrasound Room, Affiliated Hospital of Jinggangshan University, Ji’an 343000, China; ²Department of Anorectal Surgery, Affiliated Hospital of Jinggangshan University, Ji’an 343000, China; ³Imaging Department, Affiliated Hospital of Jinggangshan University, Ji’an 343000, China.

For correspondence:- Chun Xiong Email: xiong3547920991@126.com

Accepted: 19 May 2022 Published: 30 June 2022

Citation: Liao L, Huang W, Xiong C. Diagnostic efficacy of two-dimensional echocardiography combined with coronary angiogram in patients with acute myocardial infarction, and the effectiveness of atorvastatin. Trop J Pharm Res 2022; 21(6):1271-1278 doi: 10.4314/tjpr.v21i6.20

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the diagnostic significance of two-dimensional echocardiography (2DE) combined with coronary angiogram in patients with acute myocardial infarction, and to determine the effectiveness of atorvastatin.

Methods: Patients (n = 100) with acute myocardial infarction admitted in Affiliated Hospital of Jinggangshan University, Ji’an, China, were divided into control group (CG) treated with conventional therapy, and study group (EG) treated with atorvastatin, in addition to conventional therapy. The diseased vessels examined by echocardiography and coronary angiogramv were recorded and compared. The effectiveness of atorvastatin treatment was assessed by evaluating myocardial injury, oxidative stress, vascular injury and cardiac function indices, viz, left ventricular ejection fraction (LVEF), left ventricular end-diastolic internal diameter (LVEDD), left ventricular end-systolic internal diameter (LVESD), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV).

Results: The number of double and multiple lesions shown on coronary angiogram were significantly higher than those shown in echocardiography. Phosphocreatine kinase (CK), creatine kinase isoenzyme (CK-MB) and cardiac troponin T (cTnT) improved significantly in both groups after surgery, with CK-MB significantly lower in EG than those in CG at 1 and 3 days post-operation. Interleukin-6 (IL-6) was significantly lower in EG than in CG at 1 and 7 days after the surgery (p < 0.05). N-terminal B-type natriuretic peptidogen (NT-proBNP) was lower in EG than in CG on the 3rd day after surgery (p < 0.05). Superoxide dismutase (SOD) was significantly higher in EG than in the CG at 1, 3 and 7 days after surgery. The QRS scores significantly improved in both groups after surgery (p < 0.05).

Conclusion: Echocardiography, when used in combination with coronary angiogram, accurately assesses the coronary lesions in acute myocardial infarction, and atorvastatin treatment after PCI reduces myocardial injury, relieves inflammation, and promotes the recovery of cardiac function in patients.

Keywords: Acute myocardial infarction, Coronary coronary angiogram, Echocardiography, Atorvastatin