Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Efficacy of combined nebulized aerosol inhalation and pulmicort respules in the treatment of emergency pediatric laryngitis, and its effect on adverse reactions

Huazhen Wang¹, Naiqin Han¹, Nana Xu², Qingjiao Wu³, Xiaoqing Dong⁴, Zhen Han⁴

¹Department of Pediatrics, The People’s Hospital of Zhangqiu District, Jinan 250200, China; ²Department of Obstetrics, The People’s Hospital of Zhangqiu District, Jinan 250200, China; ³Department of Colour Ultrasound, The People’s Hospital of Zhangqiu District, Jinan 250200, China; ⁴Department of Emergency Surgery, The People’s Hospital of Zhangqiu District, Jinan 250200, China.

For correspondence:- Zhen Han Email: jingyanxiebianwx@163.com

Accepted: 24 May 2022 Published: 30 June 2022

Citation: Wang H, Han N, Xu N, Wu Q, Dong X, Han Z. Efficacy of combined nebulized aerosol inhalation and pulmicort respules in the treatment of emergency pediatric laryngitis, and its effect on adverse reactions. Trop J Pharm Res 2022; 21(6):1317-1322 doi: 10.4314/tjpr.v21i6.26

© 2022 The authors.
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Abstract

Purpose: To determine the efficacy of combined use of nebulized epinephrine inhalation and pulmicort respules in the treatment of emergency pediatric laryngitis and, its impact on the incidence of adverse reactions.

Methods: A total of 100 cases of pediatric laryngitis admitted in The People’s Hospital of Zhangqiu District between December 2018 and December 2020 were randomly assigned (1:1) to receive either pulmicort respules (control group) or pulmicort respules plus nebulized epinephrine inhalation treatment (study group). Outcome measures included level of effectiveness and adverse reactions.

Results: Pulmicort respules plus nebulized epinephrine inhalation treatment was associated with shorter remission time for dyspnea, wheeze, croup, and hoarseness versus pulmicort respules. The combination treatment produced higher total effectiveness of 96 % than pulmicort respules with total effectiveness of 82 % (p < 0.05). After treatment, both groups had decreased serum levels of interleukin-8 (IL-8), IL-6, C-reactive protein (CRP), and tumor necrosis factor (TNF)-α, with markedly lower levels in the group given nebulized epinephrine inhalation in combination with pulmicort respules (p < 0.05). Compared with patients given pulmicort respules only, those given combination treatments had a significantly shorter hospitalization time and a lower incidence of adverse reactions (4 vs 8 %; p < 0.05).

Conclusion: Nebulized epinephrine inhalation in combination with pulmicort respules has high safety in the treatment of emergency pediatric laryngitis, and it significantly reduces clinical symptoms, inflammatory response, and hospital stay. However, further clinical trials are required prior to its use in clinical practice.

Keywords: Nebulized epinephrine inhalation, Pulmicort respules, Pediatric laryngitis, Efficacy, Adverse reactions