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Original Research Article | OPEN ACCESS

Effect of combined vitamin D and microwave ablation of parathyroid glands on blood pressure and cardiac function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism

Xinghua Zhu1, Yingyu Li1, Lu Chen1, Chunli Du1, Jingyuan Hou2, Ailing Zhang1, Baozhen Qiu1, Jiaying Li1

1Hemopurification Center, Meizhou People’s Hospital, Meizhou 514031, China; 2Research and Experimental Centre, Meizhou People’s Hospital, Meizhou 514031, China.

For correspondence:-  Jiaying Li   Email: j7r4kx@163.com

Accepted: 19 June 2022        Published: 31 July 2022

Citation: Zhu X, Li Y, Chen L, Du C, Hou J, Zhang A, et al. Effect of combined vitamin D and microwave ablation of parathyroid glands on blood pressure and cardiac function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism. Trop J Pharm Res 2022; 21(7):1571-1577 doi: 10.4314/tjpr.v21i7.30

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effect of microwave ablation of parathyroid glands in combination with active vitamin D on blood pressure and cardiac function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism.
Methods: One hundred and twenty maintenance-hemodialysis patients with uremic secondary hyperparathyroidism admitted to Meizhou People’s Hospital were assigned to 2 groups (A and B) in the order of their admission. Each group had 60 patients. Both groups were treated with active vitamin D, while patients in group A were, in addition, subjected to microwave ablation of parathyroid glands. Blood pressure, and indices for cardiac function, thyroid function s and anemia were determined.
Results: After treatment, the blood pressure of group A was significantly lower than that of group B (p < 0.05). Moreover, after treatment, there were significant improvements in indices of cardiac function, thyroid function and anemia in group A patients, relative to group B patients.
Conclusion: Microwave ablation of parathyroid glands, when combined with active vitamin D, improves blood pressure, cardiac function and anemia status. Furthermore, the combined therapy enhances recovery of thyroid function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism. However, the combined therapy should be subjected to further clinical trials prior to application in clinical practice.

Keywords: Microwave ablation, Parathyroid glands, Active vitamin D, Hyperparathyroidism

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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