Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Therapeutic effect of percutaneous pedicle screw fixation, combined with Tongdu Huoxue decoction on thoracolumbar spine fracture

Pengfei Liu, Jianbin Nie

Department of General Trauma Surgery, The Second People's Hospital of Dongying, Dongying, Shandong 257335, China;

For correspondence:- Jianbin Nie Email: niejianbin1987@163.com Tel:+865466625638

Accepted: 12 July 2022 Published: 29 August 2022

Citation: Liu P, Nie J. Therapeutic effect of percutaneous pedicle screw fixation, combined with Tongdu Huoxue decoction on thoracolumbar spine fracture. Trop J Pharm Res 2022; 21(8):1731-1738 doi: 10.4314/tjpr.v21i8.21

© 2022 The authors.
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Abstract

Purpose: To study the therapeutic effect of percutaneous pedicle screw fixation (PPSF) combined with Tongdu Huoxue decoction on thoracolumbar spine fractures.

Methods: Ninety-eight patients with thoracolumbar spine fractures treated with PPSF were retrospectively enrolled and grouped into a study group (SG, n = 51, PPSF combined with THD), and a control group (CG, n = 47, PPSF). General surgical indices, postoperative pain, postoperative Oswestry dysfunction index (ODI index), preoperative and postoperative imaging indices, and postoperative hemodynamic indices were determined and recorded.

Results: Patients in SG exhibited significantly lower visual analog scale (VAS) scores higher than those of CG at 3, 7 and 15 days after surgery (p < 0.05). At 15 and 30 days after surgery, patients in SG exhibited significantly lower ODI index than those in CG (p < 0.05). At day 60 after surgery, Cobb angle was lower in SG than in CG, while the injured vertebral body showed higher anterior height in SG than in CG. Furthermore, FIB and D-D were lower in SG than in CG at day 7, but exhibited higher PT than CG (p < 0.05).

Conclusion: The combined application of PPSF and THD in patients with thoracolumbar fractures ameliorates postoperative pain levels, improves short-term spinal function, and significantly alters the postoperative coagulation index of patients, presumably by reducing the incidence of postoperative thrombosis. However, there is a need for further clinical trials prior to the introduction of this therapy into clinical practice.

Keywords: Percutaneous pedicle screw fixation, Tongduhuoxue decoction, Pain level, Spinal function, Coagulation index