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Original Research Article | OPEN ACCESS

Preparation and optimization of glyceryl monooleate-low molecular weight chitosan nanoparticles for delivery of morpholinopyrrolizine derivative

Amani Elsayed1 , Amany Belal2, Khaldoun Al-Sou'od3

1Department of Pharmaceutics & Industrial Pharmacy, College of Pharmacy, Taif, University, Taif, Kingdom of Saudi Arabia; 2Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif, Kingdom of Saudi Arabia; 3Department of Chemistry, Faculty of Science, Al albayt University, Mafrag, Jordan.

For correspondence:-  Amani Elsayed   Email: e.amani@tu.edu.sa   Tel:+966-567716613

Accepted: 31 August 2022        Published: 30 September 2022

Citation: Elsayed A, Belal A, Al-Sou'od K. Preparation and optimization of glyceryl monooleate-low molecular weight chitosan nanoparticles for delivery of morpholinopyrrolizine derivative. Trop J Pharm Res 2022; 21(9):1813-1821 doi: 10.4314/tjpr.v21i9.1

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To develop and optimize glyceryl monooleate–low-molecular-weight chitosan (GMO-LMWC) nanoparticles loaded with morpholinopyrrolizine derivative (NPM).
Methods: Molecular mechanics was used to determine the main driving force for the complexation between glyceryl monooleate (GMO) and chitosan. Nanoparticles were fabricated using a modified film-rehydration method. Optimization was carried out using a statistical design approach. The effects of formulation factors (concentrations of GMO, LMWC and Tween 80) on zeta potential and particle size were investigated using a 23 factorial design.
Results: A steady increase in binding energy was observed when chitosan length was increased from 22 to 142 Å, and thereafter it remained almost constant. The examined independent variables had significant effects on particle size and zeta potential. The particle size of the nanoparticles varied from 265 to 1270 nm while zeta potential was in the range of 3 – 12 mV. The optimized preparation showed a significantly low half-maximal inhibitory concentration (IC50) when compared to a free anticancer agent in the hepatocellular carcinoma (HePG-2) cell line.
Conclusion: A nanoparticulate system composed of GMO and LMWC is a potential nanocarrier for delivery of morpholinopyrrolizine derivative.

Keywords: Glyceryl monooleate, Chitosan, Pyrrolizine, Nanoparticles, Anticancer

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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