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Original Research Article | OPEN ACCESS

Effect of the combination of cognitive behavioral therapy and oral paroxetine hydrochloride in patients with post-stroke depression

Bin Tian1, Shiwei Zhang2, Qingyong Li3, Chengyong Sun4, Ya’nan Wu5, Hairong Yang2, Zhan Gao6

1Neurology Department, Dongying Traditional Chinese Hospital, Dongying City, China; 2Department of Psychiatry, Dongying Traditional Chinese Hospital, Dongying City, China; 3Neurosurgery Department, Dongying Traditional Chinese Hospital, Dongying City, China; 4Department of Psychiatry, Dongying Traditional Chinese Hospital, Dongying City, China; 5Internal Medicine-Cardiovascular Department, Zhejiang Putuo Hospital, Zhoushan City, Zhejiang Province, China; 66Neurology Department, Zhejiang Putuo Hospital, Zhoushan City, Zhejiang Province, China.

For correspondence:-  Zhan Gao   Email: shanzhatang1213@163.com

Accepted: 31 August 2022        Published: 30 September 2022

Citation: Tian B, Zhang S, Li Q, Sun C, Wu Y, Yang H, et al. Effect of the combination of cognitive behavioral therapy and oral paroxetine hydrochloride in patients with post-stroke depression. Trop J Pharm Res 2022; 21(9):1993-2000 doi: 10.4314/tjpr.v21i9.25

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To determine the effects of combined use of cognitive behavioral therapy (CBT) and paroxetine hydrochloride tablets in patients with post-stroke depression (PSD), and its effect on scores on Hamilton Rating Scale for Depression (HAMD) and Stroke Specific Quality of Life Scale (SS-QOL).
Methods: Clinical data for 96 patients with PSD who were treated in Dongying Traditional Chinese Hospital, Dongying City, China from June 2018 to June 2019 were retrospectively analyzed. Patients who met the inclusion criteria were divided into treatment group (TG, n = 48) and reference group (RG, n = 48) based on odd and even hospitalization numbers. Both groups received conventional treatment, but RG patients were in addition given clopidogrel, while TG received CBT in combination with paroxetine hydrochloride tablets. Clinical indices were evaluated in both groups before and after treatment. Moreover, therapeutic effects in the two different treatment methods on PSD, as well as on Hamilton Rating Scale for Depression (HAMD) and Stroke Specific Quality of Life Scale (SS-QOL) scores were analyzed.
Results: After treatment, TG had lower HAMD score (p < 0.001), lower scores on modified Rankin scale, and few incidences of adverse reactions at 3, 7, 15 and 30 days of treatment (p < 0.05), but higher total clinical effectiveness and mean SS-QOL score (p < 0.05), when compared with RG.
Conclusion: Combined use of CBT and oral paroxetine hydrochloride tablets may be a promising strategy for treating depression and enhancing the quality of life of PSD patients, as it greatly improves neurological deficit and prognosis. However, further clinical trials should be carried out prior to introducing it in clinical practice.

Keywords: Cognitive behavioral therapy (CBT), Paroxetine hydrochloride, Cerebral stroke, Depression, HAMD score, Quality of life

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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