Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Diagnostic value of multi-slice spiral computed tomography after adiponectin treatment of tracheal malignancies

Jian Liu¹, Degui Zu², Ying Yang¹, Maosong Deng¹, Gang Deng¹, Xin Chang¹, Xiaoming Yin¹

¹Department of Radiology, Emergency General Hospital, Beijing, China; ²Department of Interventional, Emergency General Hospital, Beijing, China.

For correspondence:- Xiaoming Yin Email: yinxianchenlun9@126.com Tel:+8613611007150

Accepted: 24 September 2022 Published: 28 October 2022

Citation: Liu J, Zu D, Yang Y, Deng M, Deng G, Chang X, et al. Diagnostic value of multi-slice spiral computed tomography after adiponectin treatment of tracheal malignancies. Trop J Pharm Res 2022; 21(10):2203-2209 doi: 10.4314/tjpr.v21i10.22

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To determine the diagnostic value of multi-slice spiral computed tomography (CT) after adiponectin treatment of tracheal malignancies.

Methods: Sixty patients with tracheal malignancies admitted to Emergency General Hospital from February 2017 to February 2021 were assigned to the study group. After physical examination, 60 healthy subjects in the same period served as the control group. All patients were treated with adiponectin. The control group was subjected to serum tumor marker testing before and after treatment, while the study group received multi-slice spiral CT before and after adiponectin treatment.

Results: The 60 patients enrolled in the study group comprised 30 cases of squamous carcinoma, 22 cases of adenocarcinoma, and 8 cases of mucosa-associated lymphoma. Multi-slice spiral CT before treatment showed that 35 patients with tracheal malignant tumors had expansive lumen hyperplasia, while 25 patients with bulging tumors had saddle-like hyperplasia with irregular surfaces, uneven margins, and mean thickness of 5.96 ± 0.65 mm in the tracheal and bronchial walls adjacent to the luminal nodule. After treatment, the thickness of the tracheal and bronchial walls adjacent to the luminal nodule decreased to a mean value of 4.65 ± 0.48 mm. Prior to treatment, the mean enhancement value of contrast-enhanced CT was 18.98±1.23 Hu, and mean tumor diameter was 3.68 ± 0.23 cm. However, after treatment, the mean enhancement value increased to 25.98 ± 1.44 Hu, while mean tumor diameter decreased to 2.54 ± 0.20 cm in the study group.

Conclusion: Multi-slice spiral CT has promising diagnostic value for patients with tracheal malignancies after adiponectin treatment. Therefore, it can potentially be used in the diagnosis of patients with tracheal malignancies.

Keywords: Multi-slice spiral CT, Adiponectin, Tracheal malignancy, Computed tomography (CT)