Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Screening of therapeutic potentials of proprioceptive exercises and topical glucosamine sulfate on pain and functional disability in knee osteoarthritis

Hifza Arif¹ , Nimra Arif¹, Noshaba Kanwal¹, Humera Tahir¹, Izhaan Akmal¹, Shaukat Hussain Munawar², Muhammad Omer Iqbal³

¹Ali-Ul-Murtaza Department of Rehabilitation Sciences, Muhammad Institute of Medical and Allied Sciences, Multan; ²Department of Pharmacology and Toxicology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan; ³Key Laboratories of Marine Drugs (Ministry of Education), Shandong Laboratory of Glycoscience and Glycoengineering, School of Pharmacy, Ocean University of China, Qingdao, China.

For correspondence:- Hifza Arif Email: hifzaa630@gmail.com Tel:+923097697428

Accepted: 28 October 2022 Published: 30 November 2022

Citation: Arif H, Arif N, Kanwal N, Tahir H, Akmal I, Munawar SH, et al. Screening of therapeutic potentials of proprioceptive exercises and topical glucosamine sulfate on pain and functional disability in knee osteoarthritis. Trop J Pharm Res 2022; 21(11):2447-2452 doi: 10.4314/tjpr.v21i11.25

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To compare the effects of proprioceptive exercises and topical glucosamine sulfate on knee osteoarthritis in terms of reducing pain and functional disability.

Methods: A single-blinded randomized clinical trial (IRCT20220115053712N1) was conducted at Muhammad Physical Therapy Clinic and Rehabilitation Center, Multan, Pakistan, from November 2021 to April 2022. Eighty-four patients enrolled and were randomized into two groups; patients in Group A were treated with proprioceptive exercises while those in Group B were treated with topical glucosamine sulfate. The Numerical Pain Rating Scale (NPRS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale were used to measure pain and functional activities at baseline, 9th and 18th sessions.

Results: The results showed that both interventions were effective, but more in Group A (p < 0.05). Group A also showed highly significant improvement in relieving the pains associated with osteoarthritis when compared to Group B (p ≤ 0.001).

Conclusion: Proprioceptive exercises are more efficient than topical glucosamine sulfate for managing knee osteoarthritis, improving functional outcomes and lowering pain intensity.

Keywords: Osteoarthritis, Proprioceptive exercises, Topical glucosamine sulfate