Dan Chen1 
,
Yili Chen2,
Leping Zhao3,
Zhongxiang Xiao3,
Linze Wang1
For correspondence:- Dan Chen Email: danluji67262987@163.com
Accepted: 15 October 2022 Published: 30 November 2022
Citation: Chen D, Chen Y, Zhao L, Xiao Z, Wang L. Effectiveness of the external application of Jidesheng snake tablets, trehalose glycerin mud, and hydroquinone cream in the treatment of melisma. Trop J Pharm Res 2022; 21(11):2453-2457 doi: 10.4314/tjpr.v21i11.26
© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To determine the effectiveness of the external application of Jidesheng snake tablets, trehalose glycerin mud, and hydroquinone cream in the treatment of melasma.
Methods: The study was conducted on 60 patients with melasma who were treated in the Affiliated Yueqing Hospital of Wenzhou Medical University between January 1, 2021, and January 31, 2022. The patients were randomly but equally assigned to two groups (study and control). The study group received Jidesheng snake medicine, glycerin, boiled water, and trehalose medicinal mud at a 10:4:2:1 combination ratio, applied to the affected parts 12 h a day for 2 - 4 weeks. After cleansing the skin, hydroquinone cream was applied to the affected area. On the other hand, the control group was treated with a similar formulation but without trehalose medicinal mud in the ratio of 10:4:2. Changes in facial melasma of the patients were observed, while the satisfaction, clinical efficacy, incidence of adverse reactions, and recurrence rate were monitored.
Results: Patients in the study group were more satisfied with the treatment than those in the control group (90 vs. 73.3 %, p < 0.05). Furthermore, treatment effectiveness was significantly higher in the study group than in the control group (93.3 vs. 70 %, p < 0.05).
Conclusion: The external application of Jidesheng medicine + glycerin + cold boiled water + trehalose is a reliable therapeutic strategy for the management of patients with melasma. It is more cost-effective, less prone to adverse reactions, and is associated with a low recurrence rate and high satisfaction.
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