Yan Liu,
Peiyun Zhou 
For correspondence:- Peiyun Zhou Email: peifuxian08695800@163.com
Accepted: 29 October 2022 Published: 30 November 2022
Citation: Liu Y, Zhou P. Efficacy of the combination of carbamazepine and pulsed-radiofrequency in the treatment of trigeminal neuralgia. Trop J Pharm Res 2022; 21(11):2473-2478 doi: 10.4314/tjpr.v21i11.29
© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the effect of the combination of carbamazepine and pulsed-radiofrequency therapy on trigeminal neuralgia (TN) and changes in inflammation status in vivo.
Methods: Ninety-seven trigeminal neuralgia patients treated in Wuhan Fourth Hospital from January 2018 to January 2021 were analyzed retrospectively. Forty-five patients treated with pulsed-radiofrequency therapy alone were designated as the control group (CG), while 52 who underwent carbamazepine and pulse-radiofrequency combination therapy were enrolled in the study group (SG). Changes in serum inflammatory factors, viz, interleukin (IL)-6, IL-1β, and tumor necrosis factor α (TNF-α), were recorded before and after treatment. Similarly, changes in pain visual analog scale (VAS) score, quality of life score, and oxidative stress index were assessed before and after treatment; so also were changes in clinical efficacy and incidence of adverse reactions.
Results: After treatment, VAS score, and levels of IL-6, IL-1β, and TNF-α in SG were lower than those in CG, while the score of quality of life in SG was higher (p < 0.05). The clinical efficacy of SG was higher than that of CG, but there was no significant difference in incidence of adverse reactions (p < 0.05).
Conclusion: The therapeutic combination of carbamazepine and pulsed-radiofrequency is more effective than pulsed-radiofrequency alone in the short-term treatment of TN in patients. It produces better relief of pain, reduces inflammation and improves patients’ quality of life. However, it does not affect the incidence of adverse reactions.
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