Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of combined administration of carboprost tromethamine and ergometrine on uterine atony-induced postpartum hemorrhage

Yinru Zhang, Ruihua Jin, Tengfei Wang, Jinyan Luo

Department of Anesthesiology, The Fourth Hospital of Shijiazhuang (Obstetrics and Gynecology Hospital Affiliated to Hebei Medical University), Shijiazhuang City 050011, Hebei Province, China;

For correspondence:- Jinyan Luo Email: jinyou26911931@163.com

Accepted: 24 November 2022 Published: 29 December 2022

Citation: Zhang Y, Jin R, Wang T, Luo J. Effect of combined administration of carboprost tromethamine and ergometrine on uterine atony-induced postpartum hemorrhage. Trop J Pharm Res 2022; 21(12):2715-2720 doi: 10.4314/tjpr.v21i12.29

© 2022 The authors.
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Abstract

Purpose: To determine the efficacy of the combined use of carboprost tromethamine and ergometrine in the prevention and treatment of postpartum hemorrhage induced by uterine atony.

Methods: A total of 66 pregnant women with postpartum hemorrhage due to uterine atony who were treated in Fuyang Women's and Children's Hospital from February 2019 to January 2022 were randomly and equally assigned to control and combination groups, respectively, based on the order of admission. The control group was treated with 0.2 mg of ergometrine maleate via intramuscular injection in the buttocks. In the combination group, the patients were also given 250 μg of carboprost tromethamine via cervical injection in addition to ergometrine. The two groups were compared in terms of volume of postpartum vaginal bleeding and hemoglobin levels, coagulation function index, clinical effectiveness and incidence of adverse reactions.

Results: There was a significant difference in total treatment effectiveness between the two groups (69.70 vs 90.91%; ê“² = 4.694, p = 0.03) with the combination group showing higher effectiveness. The volume of bleeding in the combination group at 2 h and 24 h after delivery were significantly lower than the corresponding values for the control group (p < 0.05). Comparison at 24 h postpartum showed significantly lower hemoglobin level in the combination group than in the control group (p < 0.05). Post-treatment levels of prothrombin time (PT) and thrombin time (TT) in the two groups were lower than the pre-treatment values, but the post-treatment levels in the combination group were lower than those in the control group (p < 0.05).

Conclusion: Combined administration of carboprost tromethamine and ergometrine may be a viable treatment strategy for uterine atony-induced postpartum hemorrhage. It has acceptable level of safety. However, further clinical trials are required prior to application in clinical practice.

Keywords: Carboprost tromethamine, Ergometrine, Postpartum hemorrhage, Uterine atony