Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of butylphthalide combined with edaravone d-borneol on efficacy in elderly patients with acute cerebral infarction

Li Su , Shengshan Yuan, Xinhan Yang, Yongming Jiang

Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise City, Guangxi Zhuang Autonomous Region 533000, China;

For correspondence:- Li Su Email: suli81dr@163.com Tel:+8618707861735

Accepted: 24 February 2023 Published: 31 March 2023

Citation: Su L, Yuan S, Yang X, Jiang Y. Effect of butylphthalide combined with edaravone d-borneol on efficacy in elderly patients with acute cerebral infarction. Trop J Pharm Res 2023; 22(3):665-671 doi: 10.4314/tjpr.v22i3.25

© 2023 The authors.
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Abstract

Purpose: To investigate the efficacy of butylphthalide combined with edaravone d-borneol in elderly patients with acute cerebral infarction.

Methods: From October 2020 - October 2021, 166 elderly patients suffering from acute cerebral infarction in Affiliated Hospital of Youjiang Medical College for Nationalities, Baise City, China were selected as the study subjects, and randomly divided into study and control groups, respectively, with 83 patients each. Control group was treated with edaravone d-borneol injection (15 mL of edaravone d-borneol in 100 mL of saline), while the study group was treated with butylphthalide and sodium chloride injection, combined with edaravone d-borneol injection (15 mL of edaravone d-borneol and 30 mL of butylphthalide and sodium chloride in 100 mL of saline). Clinical efficacy, as well as the levels of cytokines, viz, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-8, vascular endothelial function indicators, namely, nitric oxide (NO) and vascular endothelial growth factor (VEGF) as well as oxidative stress indicators, viz, malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) of the two groups were evaluated.

Results: Total efficacy/effectiveness in the study group was 93.98 %, which was significantly higher than 73.49 % in the control group (p < 0.05). Post-treatment, the levels of cytokines, vascular endothelial function and oxidative stress in the two groups were significantly improved compared with the values before treatment (p < 0.05). Furthermore, patients in the study group showed better treatment outcomes when compared with control group (p < 0.05).

Conclusion: The combination of butylphthalide and sodium chloride injection with edaravone d-borneol injection (15 mL of edaravone d-borneol and 30 mL of butylphthalide and sodium chloride in 100 mL of saline) is more effective than edaravone d-borneol injection (15 mL of edaravone d-borneol in 100 mL of saline) alone in the treatment of elderly patients with acute cerebral infarction, as it regulates microcirculation and improves cellular inflammatory state and oxidative stress reaction. However, further clinical trials should be conducted prior to application in clinical practice.

Keywords: Butylphthalide, Edaravone d-borneol, Elderly cerebral infarction, Clinical efficacy