Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Evaluation of two different orally disintegrating tablet formulations containing flurbiprofen inclusion complex and its solid dispersion

Emine Dilek ÕzyÄ±lmaz¹, Tansel Comoglu²

¹Department of Pharmaceutical Technology, Faculty of Pharmacy, Eastern Mediterranean University, Mersin 10, Turkey; ²Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Ankara, Turkey.

For correspondence:- Tansel Comoglu Email: comoglu@pharmacy.ankara.edu.tr

Accepted: 23 March 2023 Published: 29 April 2023

Citation: ÕzyÄ±lmaz ED, Comoglu T. Evaluation of two different orally disintegrating tablet formulations containing flurbiprofen inclusion complex and its solid dispersion. Trop J Pharm Res 2023; 22(4):705-711 doi: 10.4314/tjpr.v22i4.1

© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To prepare orally dispersible tablet formulations (ODTs) by increasing the solubility of flurbiprofen (FB), which has low water solubility.

Methods: The ODTs were prepared using direct compression method the inclusion complexes and solid dispersions with the highest solubility were further evaluated. Flurbiprofen, polyvinylpyrrolidone (PVP) solid dispersions were blended together by solvent evaporation method, while the inclusion complexes were co-formulated with beta cyclodextrin (β-CD) by kneading at three different ratios. The ODTs were characterized by differential scanning calorimetry (DSC), Fourier transform infra-red spectroscopy (FTIR) and for their micromeritic properties. In addition, the solubility properties of the inclusion complexes and solid dispersions in distilled water were compared with the solubility of flurbiprofen.

Results: The highest solubility value of PVP-FB solid dispersions was found at 1:6 (0.501 mg/mL) and for FB β-CD inclusion complex at 1:2 (0.701 mg/mL). Angle of repose ranged from 28.09 – 32.15 (o); Carr’s index from 7.59 to 10.01; and Hausner’s ration from 1.05 – 1.15. DSC and spectral studies indicate that FB did not chemically interact with either PVP or β-CD.

Conclusion: Orally dispersible tablets containing flurbiprofen β-CD complex exhibit significantly higher bioavailability than the drug alone due to its increased solubility.

Keywords: Flurbiprofen, Solubility, Orally disintegration tablets, Inclusion complex, Solid dispersion