Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Combined remifentanil/sevoflurane in paediatric tonsil surgery anesthesia: Effect on recovery time of respiration and consciousness in paediatric patients

Chao Pan¹, Yahui Xing¹, Difei Zhang², Xiaolan Liu¹, Yongxin Zhou¹, Liping Shi¹, Mengting Xu¹, Bo Zhang¹

¹Department of Anesthesiology, Taihe County People's Hospital, Fuyang City, Anhui Province, China; ²Nose and Throat Department, Taihe County People's Hospital, Fuyang City, Anhui Province, China.

For correspondence:- Bo Zhang Email: bozhang123452023@163.com Tel:+8618909681028

Accepted: 29 April 2023 Published: 30 May 2023

Citation: Pan C, Xing Y, Zhang D, Liu X, Zhou Y, Shi L, et al. Combined remifentanil/sevoflurane in paediatric tonsil surgery anesthesia: Effect on recovery time of respiration and consciousness in paediatric patients. Trop J Pharm Res 2023; 22(5):1073-1079 doi: 10.4314/tjpr.v22i5.20

© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the effectiveness of combined remifentanil/sevoflurane anesthesia on hemodynamic stability and postoperative recovery in paediatric tonsil surgery.

Methods: In this prospective study, a total of 102 paediatric patients who underwent tonsil surgery in Taihe County People's Hospital between February 2021 and April 2022 were recruited and randomized at a ratio of 1:1 to receive either propofol alone (control group) or remifentanil plus sevoflurane (study group) during paediatric tonsil surgery, with 51 patients in each group. The anaesthetic effect of the two regimens was the primary endpoint and was evaluated by monitoring the mean arterial pressure (MAP), heart rate (HR) and oxygen saturation (SpO₂) levels of the patients before anaesthesia (T0), immediately after intubation (T1), at the beginning of surgery (T2) and at extubation (T3).

Results: Remifentanil plus sevoflurane resulted in more stable MAP and HR of patients at T1, T2 and T3 than propofol alone (p < 0.05). Furthermore, patients in the two groups exhibited similar SpO₂ levels at T0, T1, T2 and T3 (p > 0.05).

Conclusion: The combined use of remifentanil and sevoflurane anaesthetics is effective in paediatric patients undergoing tonsil surgery and thus may offer a viable alternative for such clinical practice. The drug combination maintains intraoperative haemodynamic stability in patients, boosts postoperative recovery, and lowers the risk of postoperative adverse events

Keywords: Remifentanil, Sevoflurane, Paediatric, Tonsil surgery, Anaesthesia, Respiratory recovery time, Consciousness recovery time