Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Therapeutic efficacy of the combination of two surgical procedures with tamsulosin in treatment of benign prostatic hyperplasia complicated with bladder stones

Liwei Wu¹, Weihong Meng², Pinglian Chen³, Na Wang⁴, Yonghui Zhao³, Leitao Cao¹

¹Urology and Vascular Surgery Department, People's Hospital of Dingzhou, Hebei, China; ²Department of Infectious Disease, People's Hospital of Dingzhou, Hebei, China; ³Department of Pathology, People's Hospital of Dingzhou, Hebei, China; ⁴Gynecology, and Obstetrics Ultrasound Department, People's Hospital of Dingzhou, Hebei, China.

For correspondence:- Leitao Cao Email: caoleitao111@outlook.com

Accepted: 5 May 2023 Published: 30 May 2023

Citation: Wu L, Meng W, Chen P, Wang N, Zhao Y, Cao L. Therapeutic efficacy of the combination of two surgical procedures with tamsulosin in treatment of benign prostatic hyperplasia complicated with bladder stones. Trop J Pharm Res 2023; 22(5):1093-1100 doi: 10.4314/tjpr.v22i5.23

© 2023 The authors.
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Abstract

Purpose: To compare the efficacies of two surgical methods combined with tamsulosin in treating benign prostatic hyperplasia (BPH) complicated with bladder stones.

Methods: A total of 86 patients with BPH complicated with bladder stones and admitted to The People’s Hospital of Dingzhou, Hebei, from October 2021 to October 2022 were selected as subjects. The patients were equally divided into groups A and B (n = 43). Patients in group A were treated with transurethral vaporization and electro-resection of the prostate (TURP) + percutaneous nephroscopic lithotripsy (PCNL), while patients in group B were treated with TURP + holmium laser lithotripsy (HLL). Baseline clinical information, curative effect, surgery-related indicators, clinical symptoms, and recurrence were compared between the two groups of patients.

Results: At 4 weeks post-surgery, Q_max was significantly higher in group B than in group A, while IPSS score, RUV, and prostate volume were significantly lower in group B than in group A (p Ë‚ 0.05). The levels of physiological state, psychological state, social functionality and level of subjective judgment were higher in group B than in group A (p Ë‚ 0.05). The incidence of complications in group A was 11.63 %, with a recurrence rate of 6.98 %, while the corresponding values for group B were 13.95 and 4.65 %, respectively (p > 0.05).

Conclusion: The effect of TURP + HLL surgery on patients with BPH complicated with bladder stones is significantly better than that of TURP + PCNL surgery. The former also reduces clinical symptoms while improving the quality of life of patients

Keywords: Two surgical methods, Tamsulosin, Benign prostatic hyperplasia, Bladder stones, Clinical efficacy