Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Correlation of adiponectin, body mass index and waist-to-height ratio with the risk of developing gestational diabetes mellitus in hypertensive patients

Wei Jiang¹, Mingyan Sheng¹, Changdong Sun¹, Zhipeng He²

¹Department of Obstetrics, Ningbo Beilun District Peopleâ€™s Hospital, Ningbo, Zhejiang 315800, China; ²Department of Cardiology, Ningbo Beilun District Peopleâ€™s Hospital, Ningbo, Zhejiang 315800, China.

For correspondence:- Zhipeng He Email: hezhippeng@163.com Tel:+8618757499307

Accepted: 27 May 2023 Published: 30 June 2023

Citation: Jiang W, Sheng M, Sun C, He Z. Correlation of adiponectin, body mass index and waist-to-height ratio with the risk of developing gestational diabetes mellitus in hypertensive patients. Trop J Pharm Res 2023; 22(6):1291-1298 doi: 10.4314/tjpr.v22i6.19

© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To analyze the effects of abnormalities in adiponectin (APN), body mass index (BMI) and waist height ratio (WHtR) on the risk of a combination of gestational diabetes mellitus (GDM) and hypertensive disorders complicating pregnancy (HDCP).

Methods: The clinical data of 62 patients with GDM who visited Ningbo Beilun District People’s Hospital between January 2018 and June 2020 were assigned to the GDM group, and the clinical data of 38 patients with GDM and HDCP during the same period were assigned to the combination group. Blood lipid levels were measured with a fully automated biochemical analyzer. APN level was determined using double antibody sandwich enzyme immunoassay kit.

Results: The combination group had higher BMI, WHtR, family history of diabetes and hypertension, levels of hyperlipidemia, triglycerides (TG), as well as very low-density lipoprotein cholesterol (VLDL-c), and lower APN levels than the GDM group (p < 0.05) Multifactorial logistic regression results revealed that BMI, WHtR, APN, TG and VLDL-c levels may be risk factors for the occurrence of a combination of HDCP and GDM (OR > 1, p < 0.05).

Conclusion: BMI, WHtR and APN are closely related to the risk of HDCP in patients with GDM, Thus, these indicators may be used to predict, evaluate and diagnose the disease.

Keywords: Adiponectin, Gestational diabetes mellitus, Hypertensive disorders complicating pregnancy, Risk factors