Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Characteristics of intracranial infection in patients after neurosurgery, and the influence of rational use of antibiotics

Zhi-Hua Tian, Hao Zhang, Jian-bo Shen, Hai-feng Li, Gui-ping Chen, Zhi-bin Duan, Xiao-Hong Ru

Neurosurgery Department, Jincheng Peopleâ€™s Hospital, Jincheng, Shanxi, China;

For correspondence:- Xiao-Hong Ru Email: Xiaohong_Ru852@outlook.com

Accepted: 27 May 2023 Published: 30 June 2023

Citation: Tian Z, Zhang H, Shen J, Li H, Chen G, Duan Z, et al. Characteristics of intracranial infection in patients after neurosurgery, and the influence of rational use of antibiotics. Trop J Pharm Res 2023; 22(6):1321-1326 doi: 10.4314/tjpr.v22i6.23

© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the characteristics of intracranial infection (ICI) in patients after neurosurgery, and the influence of rational use of antibiotics.

Methods: The medical records of 127 patients with neurosurgery-related ICI who were admitted into Jincheng People’s Hospital, Jincheng, Shanxi, China from April 2019 to April 2022 were selected. The results of bacterial culture and drug susceptibility tests of cerebrospinal fluid were collected, and the profile of bacteria in the cerebrospinal fluid specimens of patients and the different bacterial compositions were analyzed.

Results: A total of 148 strains of pathogenic bacteria were cultured and isolated from the cerebrospinal fluid samples of 127 patients, out of which 91 strains of Gram-positive bacteria accounted for 61.49 %, and 57 strains of Gram-negative bacteria accounted for 38.51 %. The Gram-positive bacteria were Staphylococcus aureus, coagulase-negative Staphylococcus, and hemolytic Staphylococcus, while the Gram-negative bacteria comprised the pathogenic bacteria Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The Gram-positive bacteria were more sensitive to rifampicin (91.21 %), vancomycin (95.60 %), and linezolid (97.80 %), while the Gram-negative bacteria were more sensitive to imipenem (84.21 %), meropenem (75.44 %) and amikacin (77.19 %).

Conclusion: Gram-positive bacteria are the main pathogenic bacteria implicated in ICI after neurosurgery in patients. A further large-scale study is needed for better delineation of the disease presentation and prognosis.

Keywords: Neurosurgery, Intracranial infection, Antibiotics, Rational use