Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of remifentanil co-administered with propofol on stress response and postoperative complications in patients with cerebral hemorrhage undergoing surgical anesthesia

Litian Zhou¹ , Jiajia Xu², Jian Hu², Jiao Lei¹, Pinglai Yang¹

¹Department of Neurosurgery, Lishui District People's Hospital (Lishui Hospital, Zhongda Hospital, Southeast University), Nanjing City, Jiangsu Province 211200, China; ²Department of Anesthesiology, Lishui District People's Hospital (Lishui Hospital, Zhongda Hospital, Southeast University), Nanjing City, Jiangsu Province 211200, China.

For correspondence:- Litian Zhou Email: lt_zhou16@163.com Tel:+8615850512316

Accepted: 27 July 2023 Published: 31 August 2023

Citation: Zhou L, Xu J, Hu J, Lei J, Yang P. Effect of remifentanil co-administered with propofol on stress response and postoperative complications in patients with cerebral hemorrhage undergoing surgical anesthesia. Trop J Pharm Res 2023; 22(8):1733-1740 doi: 10.4314/tjpr.v22i8.27

© 2023 The authors.
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Abstract

Purpose: To determine the anesthetic effect and related indicators following concurrent administration of remifentanil and propofol in cerebral hemorrhage surgery patients.

Methods: A total of 88 cerebral hemorrhage patients admitted in Lishui People’s District Hospital, Nanjing, China, from December 2019 to December 2020, were assigned to two groups, viz, control group which received fentanyl and propofol for anesthesia, while study group was administered remientanil combined with propofol for anesthesia There were 44 patients in each group. Hemodynamic index, brain injury marker index, stress response index, awakening condition, propofol dosage, anesthetic effect, and adverse reactions were assessed and recorded.

Results: Heart rate (HR), diastolic blood pressure (DBP), and systolic blood pressure (SBP) at T2 and T3 of the two groups were less than those at T1. At T3, the study group’s HR, DBP, and SBP were substantially higher than those of control group (p < 0.05); At 12 and 24 h after operation, brain injury markers and stress response indices in study group were significantly lower compared to control group (p < 0.05), while in comparison to control group (79.55 %), the degree of anesthesia in the study group was higher (95.45 %; p < 0.05). The incidence of adverse reactions in the study group (15.91 %) was lower than in control group (43.18 %; p < 0.05).

Conclusion: Remifentanil, when combined with propofol anesthesia, stabilizes hemodynamics, protects against brain injury, and reduces stress reactions in patients undergoing cerebral hemorrhage surgery. The combination is also highly effective and safe. However, validation of these findings in larger clinical trials is required.

Keywords: Remifentanil, Propofol, Fentanyl, Cerebral hemorrhage, Anesthesia, Stress response, Adverse reactions, Hemodynamics