Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Efficacy of the combination of valsartan and hydrochlorothiazide in the treatment of hypertensive heart disease

Xin Zhou, Yuefeng Chu

Department of Cardiovascular Medicine, Lu’an Hospital of Anhui Medical University, Lu’an 237005, Anhui, China;

For correspondence:- Yuefeng Chu Email: Yuefeng_Chu@126.com

Accepted: 31 July 2023 Published: 31 August 2023

Citation: Zhou X, Chu Y. Efficacy of the combination of valsartan and hydrochlorothiazide in the treatment of hypertensive heart disease. Trop J Pharm Res 2023; 22(8):1741-1747 doi: 10.4314/tjpr.v22i8.28

© 2023 The authors.
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Abstract

Purpose: To investigate the effectiveness of the combination of valsartan and hydrochlorothiazide in managing hypertensive heart disease.

Methods: From August 2020 to October 2022, the case data of 120 patients in Lu’an Hospital of Anhui Medical University, Lu’an, China were analyzed retrospectively. Based on the different treatment options, 54 patients with hypertensive heart disease who received valsartan alone (80 mg, once daily) for 3 months were placed in control group (CG), while 66 patients who received valsartan combined with Systolic blood pressure (SBP), therapeutic effect, diastolic blood pressure (DBP), and incidence of adverse effects were also recorded for CG and SG.

Results: In the SG, there were significant reductions in SBP, DBP, LVMI and LVPWT compared to CG, while EF showed significant increase after treatment (p < 0.05). In both groups, SBP, DBP, LVMI and LVPWT decreased significantly after treatment compared to pre-treatment values, but EF however showed a significant increase (p < 0.05). In the SG, there was a significant increase (p < 0.05) in the total effective rate compared to CG and there was also a significant reduction (p < 0.05) in the total incidence of adverse effects compared to CG.

Conclusion: Valsartan combined with hydrochlorothiazide is more effective in treating patients with hypertensive heart disease than valsartan monotherapy alone. However, the combination treatment should be subjected to further clinical trials prior to its introduction into clinical practice.

Keywords: Valsartan, Hydrochlorothiazide, Hypertensive heart disease, Cardiac function indices