Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Efficacy of Jade Wind-Barrier Powder in adjuvant treatment for children with asthma, and its influence on IFN-γ, immunoglobulin and mucin

Huifen Wu, Pengfei Li, Jingying Guan, Jiaxuan Hong

Department of Pediatrics, Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang Province 311200, China;

For correspondence:- Jiaxuan Hong Email: hjx_jiaxuan789@163.com Tel:+8613867170152

Accepted: 30 August 2023 Published: 30 September 2023

Citation: Wu H, Li P, Guan J, Hong J. Efficacy of Jade Wind-Barrier Powder in adjuvant treatment for children with asthma, and its influence on IFN-γ, immunoglobulin and mucin. Trop J Pharm Res 2023; 22(9):1959-1965 doi: 10.4314/tjpr.v22i9.26

© 2023 The authors.
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Abstract

Purpose: To study the effects of Jade Wind-Barrier Powder on peripheral blood interferon-γ (INF-γ), immunoglobulin and sputum mucin in children with asthma.

Methods: Sixty-six children with asthma in remission stage were randomly separated into study and control groups. The control group was treated with budesonide formoterol powder inhaler, while the study group was orally administered Jade Wind-Barrier Powder. The therapeutic effects, and INF-γ, immunoglobulin and mucin levels in sputum, as well as pulmonary function parameters in both groups were determined. The number of acute relapses of asthma and duration of wheezing were counted in the patients. The relative effectiveness of Jade Wind-Barrier Powder in the treatment of asthma in the children was also assessed.

Results: The overall response rate (ORR) in the study group was 93.94 %, which was higher than in the control group (75.76 %, p < 0.05). Over the 6-month period of follow-up, the frequency of acute attacks of asthma in the study group was significantly lower while the duration of wheezing during attack was also shorter than in the control group. After treatment, pulmonary function indices in the study group were higher, whereas mucin 5AC (MUC5AC), mucin 5B (MUC5B) and mucin 1 (MUC1) levels in sputum were lower than in the control group (p < 0.05).

Conclusion: Jade Wind-Barrier Powder exerts therapeutic effect in children with asthma. However, further clinical trials across multi-centers are required to validate it its use in clinical practice.

Keywords: Asthma in children, Jade Wind-Barrier powder, Peripheral blood interferon-γ, Immunoglobulin, Mucin