Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Meta-analysis of the effect of losartan relative to other angiotensin receptor antagonists on serum uric acid level

Jinjie Zhou¹, Yongwei Zhang², Lin Cheng³

¹Department of Cardiovascular Internal Medicine, Huangpu Branch, Shanghai Ninth People´s Hospital, 200011, China; ²CCU, TEDA International Cardiovascular Hospital, Tianjin 300457, China; ³Bei Tai Ping Zhuang outpatient Department, Central Medical Branche of PLA General Hospital, Beijing, China.

For correspondence:- Lin Cheng Email: summer791008@126.com

Accepted: 28 August 2023 Published: 30 September 2023

Citation: Zhou J, Zhang Y, Cheng L. Meta-analysis of the effect of losartan relative to other angiotensin receptor antagonists on serum uric acid level. Trop J Pharm Res 2023; 22(9):1999-2008 doi: 10.4314/tjpr.v22i9.31

© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To systematically analyze the disparity in uric acid reduction between losartan and other angiotensin receptor antagonists.

Methods: A computer-based search was conducted in databases including EMBASE, PubMed, Wanfang, CNKI, Ovid MEDLINE, and Web of Science to identify original literature comparing the impact of losartan with other angiotensin receptor antagonists on blood uric acid levels. Utilizing the Cochrane Collaboration bias risk tool, a quality assessment of the included randomized controlled studies was conducted.

Results: A total of 12 publications were obtained, consisting of 6 randomized controlled studies and 6 cohort studies. Five of the twelve publications assessed the impact of losartan compared to valsartan on blood uric acid levels. The heterogeneity analysis yielded I² = 98 % (p < 0.01), indicating substantial variability among the studies. Findings indicated that losartan was more effective than valsartan in reducing blood uric acid levels (SMD = -3.26, 95 % CI (-5.01 to 1.51), p < 0.05). Four publications investigated the impact of losartan versus telmisartan on blood uric acid levels. The results revealed that losartan had a greater effect in reducing blood uric acid levels compared to telmisartan (SMD = -1.77, 95 % CI (-3.411 to -0.13), p < 0.05).

Conclusion: Among the angiotensin receptor antagonists used as antihypertensive drugs, losartan stands out for its significant ability to reduce uric acid levels. This finding provides a strong evidence-base for making clinical medication decisions.

Keywords: Losartan, ValsartanAngiotensin receptor antagonists, Blood uric acid, Meta-analysis