Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effectiveness of the combination of terbutaline and budesonide inhalation in treating acute bronchial asthma during pregnancy

Guozhi Zhang¹, Lina Zhou², Shanshan Guo³, Mei Wang⁴, Ling Han⁵

¹Department of Respiratory, PLA Strategic Support Force Characteristic Medical Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China; ²Department of Health Care, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China; ³General Family Medicine, PLA Rocket Force Characteristic Medical Center, Gilead Sciences, Beijing 100020, China; ⁴Department of Cardiothoracic Surgery, PLA Rocket Force Characteristic Medical Center, Gilead Sciences, Beijing 100020, China; ⁵Clinical Development, Gilead Sciences, Beijing 100020, China.

For correspondence:- Ling Han Email: star1632023@163.com Tel:+8613601318447

Accepted: 4 October 2023 Published: 31 October 2023

Citation: Zhang G, Zhou L, Guo S, Wang M, Han L. Effectiveness of the combination of terbutaline and budesonide inhalation in treating acute bronchial asthma during pregnancy. Trop J Pharm Res 2023; 22(10):2225-2233 doi: 10.4314/tjpr.v22i10.26

© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the therapeutic benefits of terbutaline sulfate aerosol inhalation combined with budesonide, and its influence on pulmonary function in pregnant women suffering from acute bronchial asthma attacks.

Methods: A total of 100 pregnant patients diagnosed with acute bronchial asthma in PLA Strategic Support Force Characteristic Medical Center, Beijing, China were divided into control and study groups (n = 50 each). Control group received aerosol inhalation of normal saline along with standard treatments, viz, oxygen inhalation, sputum aspiration, anti-infection measures, and maintenance of water-electrolyte balance. Study group received combined terbutaline sulfate and budesonide aerosol inhalation in addition to standard treatment. Both groups underwent a 7-day treatment course, with inhalation therapy twice daily.

Results: Study group showed significantly shorter relief times for cough, wheezing, and chest tightness compared to control group (p < 0.05). After treatment, 92.0 % of patients in study group exhibited improvement or relief from their symptoms, compared to 80.0 % in control group (p < 0.05). Pulmonary function indices, including first vital capacity (FVC), forced expiratory volume in one second (FEV1), peak expiratory flow (PEF), and FEV1/FVC, improved in both groups after treatment. Study group exhibited significantly lower laboratory indices, including immunoglobulin E (IgE), C-reactive protein (CRP), and eosinophils (EOS) compared to control group (p < 0.05).

Conclusion: The combination of inhalation therapy of terbutaline sulfate with budesonide in pregnant women experiencing acute bronchial asthma demonstrates significant enhancements in clinical effectiveness, pulmonary function, and laboratory parameters. Clinical trials of this combined therapy should be carried out in other locations to ascertain the effect of population variation on treatment efficacy.

Keywords: Budesonide, Terbutaline, Pregnancy, Asthma, Aerosol inhalation therapy