Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of Dentong Xiaoyanling and tinidazole gargle on periodontal parameters in chronic periodontitis, gingival sulcus factor and oral health

Junxian Xu, Lanfang Lu

Department of Stomatology, Chun'an County Traditional Chinese Medicine Hospital, No. 1 Xin 'an West Road, Qiandaohu Town, Chun 'an County, Hangzhou City, Zhejiang Province 311700, China;

For correspondence:- Lanfang Lu Email: lulanfang3051201@163.com Tel:+8657165092541

Accepted: 01 November 2023 Published: 30 November 2023

Citation: Xu J, Lu L. Effect of Dentong Xiaoyanling and tinidazole gargle on periodontal parameters in chronic periodontitis, gingival sulcus factor and oral health. Trop J Pharm Res 2023; 22(11):2373-2380 doi: 10.4314/tjpr.v22i11.18

© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effect of concentrated tinidazole gargle combined with Dentong Xiaoyanling on chronic periodontitis.

Methods: Ninety-six (96) patients with chronic periodontitis admitted in Chun’an County Traditional Chinese Hospital, Qiandaohu Town, China between January 2021 and December 2022 were randomly divided into two groups: control group (treated with concentrated tinidazole gargle) and study group (treated with concentrated tinidazole gargle + Dentong Xiaoyanling). Periodontal indicators, Gingival sulcus factor (GSF), oral health status, clinical efficacy and adverse reactions were compared between the two groups.

Results: There were no significant changes (p > 0.05) in periodontal indicators, GSF or oral health score between the two groups prior to therapy. However, following treatment with Dentong Xiaoyanling and/or concentrated tinidazole gargle, the periodontal indicators, GSF and oral health score of the two groups reduced significantly (p < 0.05), with more pronounced reductions in the study group. Clinical efficacy in the group treated with a combination of concentrated tinidazole gargle and Dentong Xiaoyanling was 91.67 %, which was significantly higher (p < 0.05) than that of control group (75 %). Furthermore, there was no significant difference in the incidence of adverse reactions between the two groups pre- and post-treatment (p > 0.05).

Conclusion: Treating chronic periodontitis with concentrated tinidazole gargle + Dentong Xiaoyanling alleviates local inflammatory reaction of gums, enhances recovery from symptoms and improves oral health. Future approaches will require a larger sample size from diverse clinical settings to confirm the effectiveness of this approach.

Keywords: Tinidazole gargle, Dentong Xiaoyanling, Chronic periodontitis, Oral health, Gingival sulcus factor (GSF), Periodontal index