Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of the combination of HA380 hemoperfusion with CVVHDF on inflammatory indices and microcirculation in early septic shock

Guochao Zhu¹, Jing Zhang², Mei Ye¹, Jiao Du¹, Chao Liu¹, Huaping Liu¹, Ruixue Li¹, Liang Sun¹

¹Department of Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China; ²Department of ENT, Affiliated Hospital of Jianghan University, Wuhan, Hubei 430015, China.

For correspondence:- Liang Sun Email: sunliang69@tom.com Tel:+862782440769

Accepted: 2 January 2024 Published: 30 January 2024

Citation: Zhu G, Zhang J, Ye M, Du J, Liu C, Liu H, et al. Effect of the combination of HA380 hemoperfusion with CVVHDF on inflammatory indices and microcirculation in early septic shock. Trop J Pharm Res 2024; 23(1):183-190 doi: 10.4314/tjpr.v23i1.23

© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To determine the clinical efficacy of combining HA380 hemoperfusion with continuous veno-venous hemodialysis filtration (CVVHDF) in early-stage septic shock.

Methods: Data from 107 patients admitted to Affiliated Hospital of Jianghan University, China from January 2020 to January 2022 were analyzed. They were divided into control group (53 cases, on conventional treatment + CVVHDF) and study group (54 cases, on conventional treatment + CVVHDF + HA380 hemoperfusion). Changes in vital signs, renal function, inflammatory markers, microcirculatory indices and disease severity were compared before and after treatment. Adverse reactions and prognostic indicators were also recorded.

Results: In both groups, heart rate (HR), respiratory rate, urea nitrogen (BUN), blood creatinine (Scr), calcitoninogen (PCT), c-reactive protein (CRP), interleukin (IL)-1, tumor necrosis factor (TNF)-α, Sequential Organ Failure Assessment Score (SOFA) and Acute Physiology and Chronic Health Status Scoring System II (APACHE II) decreased after 7 days of treatment. These improvements were more significant in study group relative to control group. MAP, MFI and PPV showed an elevation in study group when compared to control group. Both groups showed no marked difference in the incidence of adverse reactions (7.55 vs. 12.96 %). The study group had shorter intensive care unit (ICU) stays, duration of mechanical ventilation and total hospital stays in comparison to control group (p < 0.05).

Conclusion: The combination of HA380 hemoperfusion and CVVHDF effectively improves renal function, controls septic shock, inhibits the inflammatory response, enhances microcirculation and improves short-term prognosis without significantly increasing adverse reactions. This treatment modality seems promising for early-stage septic shock pending outcomes of evaluating their long-term efficacy and prognosis.

Keywords: Septic shock, HA380 hemoperfusion, Venous hemodialysis filtration, Inflammatory index, Microcirculation